Iron metabolism

Question 1

Low iron in men or post-menapausal women should always be followed up for possible_____________?

Answer 1

GI bleed

Question 2

Why don’t vegetarians absorb iron as well as people who eat meat?

Answer 2

Non-heme (Fe3+) in veggies is taken up less avidly than Heme iron (Fe2+?) found in meat.

Question 3

Treatment for Hemochromatosis?

Answer 3

Phlebotomy!!!!!!

Question 4

Deficiency in HFE gene (autosomal recessive)

HFE gene codes for hepcidin so defect = decr. hepcid and iron overload

Answer 4

HFE Hemochromatosis

Question 5

Ferritin of

Answer 5

Iron deficiency anemia!!!!!

Question 6

Wherer is Fe primarily absorbed in the body?

Answer 6

Proximal small bowel (duodenum)

Question 7

What is ferric iron?

Answer 7

Fe3+, found in veggies, insoluble at physiological pH

-oxidized to Fe2+(ferrous) in acid of stomach

Question 8

Which is absorbed better, Fe2+ or Fe3+?

Answer 8

Fe2+ !!!!!

ferrous
ferrous
ferrous

Question 9

How is Fe3+ transported in blod?

Answer 9

transferrin

Question 10

How is Fe2+ stored in cells?

Answer 10

ferritin

Question 11

Key regulator of systemic iron homeostasis?

Answer 11

Hepcidin

Question 12

Increased hepcidin = _________ intracellular iron. Which can lead to what?

Answer 12

increased

Iron deficiency seen in Anemia of Chronic Disease

Question 13

Decreased hepcidin results in ______ extracellular iron.

Answer 13

increased

**leads to iron overload

Question 14

1 mL blood = _____ mg Fe?

Answer 14

0.5

Question 15

Classic triad of Hereditary Hemochromatosis?

Answer 15

• DM
• hepatomegaly
• Hyperpigmentation

Question 16

Deficiency in HFE gene (autosomal recessive)

HFE gene codes for hepcidin so defect = decr. hepcidin and iron overload

Answer 16

HFE Hemochromatosis

Question 17

Where is Fe primarily absorbed in the body?

Answer 17

Proximal small bowel (duodenum)