Pharm - Basics

Question 1

2 types of Ach receptors

Answer 1

• nicotinic and muscarinic

Question 2

nicotinic Ach receptors

Answer 2

• ligand gated Na+/K+ channels

Question 3

muscarinic Ach receptors

Answer 3

• G-protein coupled receptors that usu act through 2nd messengers

Question 4

muscarinic Ach receptor subtypes

Answer 4

M1, M2, M3, M4, M5

Question 5

Alpha-1 (q)

Answer 5

• increase vascular smooth muscle contraction
• increase pupillary dilator muscle contraction (mydriasis)
• increase intestinal and bladder sphincter muscle contraction

Question 6

Alpha-2 (i)

Answer 6

• decreases sympathetic outflow
• decreases insulin release
• decreases lipolysis
• increases platelet aggregation

Question 7

Alpha-2 (i)

Answer 7

• decrease sympathetic outflow
• decrease insulin release
• decrease lipolysis
• increase platelet aggregation

Question 8

Beta-1 (s)

Answer 8

• increase heart rate
• increase contractility
• increase renin release
• increase lipolysis

Question 9

Beta-2 (s)

Answer 9

• increase vasodilation and bronchodilation
• increase heart rate
• increase contractility
• increase lipolysis
• increase insulin release
• decrease uterine tone (tocolysis)
• uterine muscle relaxation?
• increase aqueous humor production

Question 10

what are the 4 sympathetic receptors

Answer 10

• adrenergic receptors - alpha1, alpha2, beta1, beta2

Question 11

what are the 3 parasympathetic receptors?

Answer 11

• M1, M2, M3

Question 12

M1 (q)

Answer 12

• CNS enteric nervous system

Question 13

M2 (i)

Answer 13

• decrease heart rate and contractility of atria

Question 14

M3 (q)

Answer 14

• increase exocrine gland secretion (e.g. lacrimal, salivary, gastric acid)
• increase gut peristalsis
• increase bladder contraction, bronchoconstriction
• increase pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)

Question 15

Dopamine receptor types

Answer 15

D1 -stimulatory

D2- inhibitory

Question 16

D1 (s)

Answer 16

relaxes renal vascular smooth muscle

Question 17

D2 (i)

Answer 17

modulates transmitter release, especially in brain

Question 18

Histamine receptor types

Answer 18

H1- (q)

H2- stimulatory

Question 19

H1

Answer 19

• increases nasal and bronchial mucus production
• increases vascular permeability
• contraction of bronchioles, pruritis and pain

Question 20

H2

Answer 20

• increase gastric acid secretion

Question 21

vasopression receptor types

Answer 21

-V1 - (q)

V2 (s)

Question 22

H1 (q)

Answer 22

• increases nasal and bronchial mucus production
• increases vascular permeability
• contraction of bronchioles, pruritis and pain

Question 23

H2 (s)

Answer 23

• increase gastric acid secretion

Question 24

vasopressin receptor types

Answer 24

-V1 - (q)

V2 (s)

Question 25

V1 (q)

Answer 25

• increase vascular smooth muscle contraction

Question 26

V2 (s)

Answer 26

• increase H2O permeability and reabsorption in the collecting tubules of the kidney (V”2” is found in the “2” kidneys)