Viral immune interactions. Flashcards
1
Q
EBV
A
Avoiding immune system
Balancing immune surveillence.
2
Q
EBV - avoiding the immune system.
A
Molecular mimicry.
Induction of cytokines
Antigen presentation
Inhibition of apoptosis.
3
Q
EBV molecular mimicry
A
viral homologues of cellular interleukins e.g. EBV vIL-10.
4
Q
EBV induction of cytokines
A
LMP1 may do this.
5
Q
EBV antigen presentation.
A
Block presentation of class II epitope. Prevent peptide binding. Decrease expression of TAP proteins and HLA class 1.
6
Q
EBV antigen presentation, preventing peptide binding.
A
e.g. EBNA1 which must be expressed even in latency has a glycine-alanine repeat which inhibits proteolytic degradation prior to presentation.
7
Q
EBV antigen presentation decreasing expression of TAP and HLA proteins.
A
LMP1 gene product appears to do this.
8
Q
EBV balancing immune surveillence.
A
Must allow some immune surveillence or would kill host (not optimal).
