host modulation Flashcards
define host modulation
altering the patient’s defense responses to help the body limit damage to the periodontium from infections such as periodontitis
what is the major contributor to disease pathogenesis
host response to periodontal pathogens
what are the bad cytokines
proinflammatory mediators-interleukin-1-alpha, IL-6, and TNFa
potential host-modulating agents
doxycycline, bisphosphonates
what is antibacterial dose
dose of doxycycline high enough to kill bacteria
what is sub-antibacterial dose
dose of doxycycline that are below the bacterial killing or inhibiting dose
what does doxycycline at sub-antibacterial doses alter?
the body defenses by inhibiting part of the destruction that can occur in perio
doxycycline at sub-antibacterial dose reduces what?
decreases the effects of the enzyme collagenase
side affects of NSAIDs
- gastrointestinal problems
- bleeding
- kidney or liver impairment
effects of NSAIDs in the oral cavity
- reduce tissue inflammation by inhibiting PGE2
- inhibit osteoclast activity
- slow the rate of alveolar bone loss associated with periodontitis
what is NSAIDs
nonsteriodal anti-inflammatory drugs
-ibuprofen, aspirin, naproxen
what can bisphosphonates inhibit?
resorption of bone by altering osteoclastic activity
side effects of bisphosphonates
-ostenoecrosis of the jaw
what is the one agent that has been approved for adjunctive use during perio surgery
an enamel matrix protein called emdogain
what is the only approved agent for periodontal management
low doses of doxycycline
