D7 Pharmaceutical Suspensions

Question 1

How is alginate a serendipitous product?

Answer 1

Originally designed for carrier of radiological contrast agent
- secondary discovery to relieve heartburn

Question 2

If pH drops below 3.5 (the pKa of alginic acid) it will…

Answer 2

Precipitate as a gel

Question 3

Function of carbonate or bicarbonate

Answer 3

Produces CO2 trapped in gel to produce a low density raft that can float on stomach contents and prevent stomach contents from refluxing into the oesophagus

Question 4

Carbomer uses

Answer 4

Suspending agents, viscosity- increasing material

Question 5

Parahydroxybenzoates (parabens) uses

Answer 5

Antimicrobial preservatives - longer chain esters have a greater antimicrobial activity

Question 6

Sodium saccharin uses

Answer 6

300-600 times sweeter than sugar

Suitable for diabetics

Question 7

Sodium hydroxide (NaOH) uses

Answer 7

Adjust the pH, at low pH values the alginate may precipitate; max viscosity pH 5-9
Increases pH to counter balance acidic carbomer lowering pH

Question 8

Gaviscon _____ product for Peptac Liquid

Answer 8

Innovator

Question 9

HDPE

Answer 9

High density polyethylene

- not impermeable to vapours

Question 10

PET

Answer 10

Polyethylene terephthalate

-less permeable to oxygen than HDPE