Chronic Lymphocytic Leukemia Flashcards

1
Q

Adults, kids, or both?

A

Adults ONLY

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2
Q

4 things you must know!

A

Small, MATURE lymphocytes

same as SLL (small lymphocytic lymphoma)

B-cell, but CD5+ (weird, usually a T-cell marker)

Long but inexorable course

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3
Q

Clinical findings in CLL?

A

age > 40

asymptomatic at first

later, organ infiltration

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4
Q

Cell markers that will be positive in CLL?

A

B-cell antigens (ie. CD19, 20, 21)

CD5+ !!!!!!

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5
Q

Negative marker to differentiate from lymphoblastic?

A

no TdT in CLL

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6
Q

lab findings in CLL?

A

increased WBC

Hypogammaglobulinemia

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7
Q

genetic mutation associated with CLL:

A

bcl-2

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8
Q

What dose a mutated bcl-2 do?

A

makes cells immortal

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9
Q

Splenomegaly withOUT lymphadenopathy

Pancytopenia

TRAP+

A

Hairy Cell Leukemia

**obviously have hairy cells present too

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10
Q

Male:Female prevalence in HCL?

A

5:1 — significantly more males

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11
Q

Surface markers present in HCL?

HCL negative for?

**this is on the test probably

A

+B-cell antigens

+CD25

+CD11c

**NO CD5

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12
Q

Lab finding ALWAYS present in HCL?

A

Monocytopenia

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13
Q

4 things you must know about Prolymphocytic Leukemia:

A

Prolymphocytes

Splenomegaly withOUT lymphadenopathy

Rare

Aggressive

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14
Q

Lab findings in Prolymphocytic Leukemia:

A

Increased WBC

decreased Hgb

decerased Plts

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15
Q

Four things you must know about Large Granulated Lymphocyte Leukemia:

A

Large granulated lymphocytes

T-cell

Neutropenia

Long survival

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16
Q

Clinical findings in LGL?

A

Infections from neutropenia

Long survival

17
Q

Immunophenotype of LGL?

A

T-cell