Thursday - Krafts - multiple myeloma

Question 1

multiple myeloma things you must know

Answer 1

monoclonal plasma cell proliferation
monoclonal gammopathy
decreased normal immunoglobulins
osteolytic lesions - look real bad on x ray - leads to hypercalcemia

M spike

Question 2

types of immunoglobulins over produced in MM

Answer 2

IgG in 60% of cases
IgA in 20% of cases
IgD or IgE in rare cases
Never IgM

Question 3

blood finding of MM

marrow findings

Answer 3

Blood: anemia, rouleaux, “flame cells” “russell bodies” “dutcher bodies” “Mott cells”
Marrow: plasma cells, amyloid

Question 4

Waldenstrom macroglobulinemia

Answer 4

B cells
Lymphoplasmacytoid lymphoma
IgM
Hyperviscosity syndrome

Question 5

MM SSx

Answer 5

bone pain - 80%

bruizing or bleeding from decreased platelets

infections from decreased levels of normal Igs

^ Ca

Triad - anemia, bone pain , renal failure*

Question 6

Biphosphonates

Answer 6

inhibit bone resorption