4-3 Immuno

Question 0

Skin, epidermis, mucus is considered

Answer 0

Mechanical

Question 1

First line of defense

Answer 1

Innate

Question 2

Complement components become______ which recruit cells

Answer 2

Opsonins

Chemoatrractants

Question 3

Associate to form MAC

Answer 3

C5b-9

Question 4

C3b is called?

Answer 4

Opsonin

Question 5

Examples of PAMPS

Answer 5

Cpg dna
Flagellin
Rna ds
Peptidoglycan
Lps

Question 6

Present on NK cells surface specific for MHC 1

Answer 6

KIRs

Question 7

Secreted by NK cells to kill infected cells

Answer 7

Perforina

Granzymes

Question 8

Nkt Recognize antigens presented by?

Answer 8

CD1

Question 9

T or f? Adaptive immune response is the ability to respond to a variety of antigens each in a specific manner

Answer 9

True

Question 10

Downrwgulates th2 and1 responses

Answer 10

Inf gamma

Il10

Question 11

Activatiob of t cells is regulated via negative feedback loop involving ?

Answer 11

CTLA 4

Question 12

Paired with ICam 1 in t cell

Answer 12

LFA1

Question 13

Ctla4 binds with

Answer 13

Cd80/86

Question 14

Cd28 on t cells bind to _____ on apcs

Answer 14

Cd80/86

Question 15

T or f: costimilation is needed (ctla4) or else t cell will be unreponsive

Answer 15

True

Question 16

Recombinant antibody that binds to ctla4

Answer 16

Ipili mumab

Question 17

Types of abnormal tissues responses

Answer 17

HAI
Hypersensitivity
Autoimmunity
Immunodeficiency

Question 18

Antibody mediated hypersensitivity

Answer 18

1-3

Question 19

Mild type 1

Answer 19

Asthma

Anaphylaxis

Question 20

________ from quinidine

Answer 20

Thrombocytopenic purpura

Question 21

inappropriate exp of class2 mhc on membranrd of cells that normally to not express mhc.. Is a mechanism of autoimmunity

Answer 21

True

Question 22

Consequences of ID

Answer 22

Increased susceptibility and prolonged duration

Question 23

Failure of thymus to develop

Answer 23

DiGeorges syndrome

Question 24

Toxic to lymphocytes

Answer 24

Deoxy ATP

Question 25

ID caused by extrinsic factors

Answer 25

Aids

Question 26

4 immunosuppressants targets

Answer 26

Secretory proteins
Cell bound receptors
Transduction
Transcription

Question 27

Cyclosporine is an example of _______ inhibitor

Answer 27

Calcineurim

Question 28

Cyclosporin binds to

Answer 28

Cyclophilin

Question 29

CSA w ______ is the sole immunosuppressant for cadaveruc transplantation

Answer 29

Glucocorticoids

Question 30

Bind to FK binding protein wc inhibits calcineurin

Answer 30

Tactolimus

Pimecrolimus

Question 31

Uses of tacro and pimecrolimus

Answer 31

Derma dses

Question 32

Tacrolimus and pimecrolimus are macrolide antibiotic produced by

Answer 32

Strel tsukubaensis

Question 33

Sirolimus is classified as

Answer 33

Mtor inhibitors

Question 34

Sirolimus binds to

Answer 34

FK506 binding protein 12

Question 35

Better bioavailability sirolimus analogs

Answer 35

Ever olimus

Question 36

Inhibits inosine mP dehydrogenaSe

Answer 36

MMF (putine antagonists)