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Flashcards in 4 - Autoimmunity Mechanisms Deck (19)
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1

What is the definition of autoimmunity and an autoimmune disease?

2

What are the two patterns of autoimmune disease?

- Organ specific

- Non-Organ specific

3

What are the self antigens in the following conditions/?

4

Which systems in the body do auto-immune diseases commonly affect?

- Nervous disease

- Respiratory disease

- Endocrine disease

- Joint diseases

- Haematological disease 

5

What type of hypersensitivity reactions are the following autoimmune diseases?

6

What are the two mechanisms of tissue damage in autoimmune conditions?

- Autoantibodies

- Autoreactive T Cells

7

What are the five criteria for diagnosing an autoimmune condition?

Immunomodulatory therapy is monoclonal antibodies

8

What are some autoimmune conditions that have primary autoantibodies?

9

What are some autoimmune antibodies that have secondary autoantibodies?

10

How can we detect autoantibodies/autoreactive T cells?

- Biopsy tissue to see lymphocytes

- Immunofluroescene of serum on healthy tissue 

- Serum levels of autoantibodies

11

What are some autoimmune conditions that a mother may have that can be passed onto the baby?

IgG crosses over placenta so baby will experience symptoms for first 6 months of life

12

What causes induction of autoimmunity?

Loss of tolerance

13

What are some triggers of autoimmunity?

- Genetic Factors

- Environmental Factors

14

What are some infections that can lead to autoimmune conditions?

Mimicry - infection has antigen similar to a self antigen!!

15

What are some drugs that can lead to autoimmune syndromes?

16

What are some of the autoantibodies for SLE?

- ANA 

- Anti-dsDNA

17

What therapeutic strategies can be used for treated autoimmune conditions?

- Autoantibodies: plasmapheresis and monoclonal antibodies

 

- Autoreactive T Cells: immunosupressive drugs and monoclonal antibodies 

 

- Tissue damage: antiinflammatory drugs e.g steroids 

 

- Organ dysfunction: replacement therapy or surgery

 

18

What do all monoclonal antibody drugs end in?

- MAB

 

Very few side effects as targeted to specific protein

19

What therapeutic strategies are used for the following autoimmune diseases?

Think about disease process to think about therapy