4 - Bone Marrow Structure and Function Flashcards
1
Q
What are the 5 structures of the bone?
A
- Periosteum
- Compact bone
- Haversian canals
- Spongy bone
- Bone marrow
2
Q
What is the most primitive cell in the bone marrow and what two cells can it differentiate into?
A
- Haematopoietic stem cell
- Differentiates into common myeloid progenitor or common lymphoid progenitor
3
Q
What is the most common form of polycythaemia and what causes it?
A
Stress polycythaemia - not enough water (alcohol, tobacco and diuretic use)
4
Q
What causes true secondary polycythaemia?
A
chronic hypoxia from heart or lung disease
5
Q
What is a rare cause of polycythaemia?
A
primary proliferative polycythaemia - abnormal clone marrow cell chronically overproduces RBCs
6
Q
What are three causes of thrombocytopenia?
A
- Chronic liver disease (impaired TPO production)
- ITP (antibodies against platelets)
- Hypersplenism (overactive spleen)
7
Q
What are three causes of thrombocytosis?
A
- Reactive thrombocytosis - cancer, chronic infection or inflammation)
- Primary thrombocythemia - abnormal clone marrow cell chronically overproduces platelets
- Post splenectomy thrombocytosis
