Flashcards in 4 Dysmorphology and Teratogens Deck (17):
what is a malformation?
poor formation of tissue
-intrinsically abnormal developmental process
-likely to be genetic
what is a deformation?
unusual force on normally maturing tissue
-club foot, overlapping toes, torticollis
what is a disruption?
breakdown of normal tissue (could get an umbilical cord wrap)
what is a dysplasia?
abnormal organization of cells in tissue
what is a syndrome?
multiple anomalies thought to be pathogenically related
what is a sequence?
a casacade of effect from a single known anomaly or mechanical factor
what is a field defect
derived from the disturbance of a single developmental field which then affects the fields around it
what is association
the non-random occurrence of multiple anomalies that can not be explained by chance
what are multiple congenital anomalies?
two or more structural primary defects in 2 or more body areas / embryologically different areas
what is the difference betweem a syndrome, sequence, and association?
syndrome: genetic factors
what is the piere robin sequence?
micrognathia, glossoptosis, cleft -palate
what is the potter sequence?
lack of fetal urine, anhydromnios, fetal compression, pulmonary hypoplasia, death
OEIS and holoprocencephaly are examples of what?
what is vacterl?
-vertebral anomalies, anal atresio, cardiovascular, tracheoesophogeal fistula, esohpogeal atresia, renal, limb
-An Assoiation disorder (unknown cause)
in the first semester, wht affect do teratogens typically have?
in the 2nd and 3rd trimester, what affect do teratogens have?