Secretions

Question 1

Share the same alpha subunit

Answer 1

FSH
LH
TSH
B-hCG

Question 2

Alpha cells of pancreas

Answer 2

Glucagon

Question 3

Beta cells of pancreas

Answer 3

Insulin

Question 4

Delta cells of pancreas

Answer 4

Somatostatin

Question 5

cAMP Signaling Pathway

Gs

Answer 5

FLAT ChAMP

FSH
LH
ACTH
TSH
CRH
hCG
ADH (V2)
MSH
PTH

Question 6

cGMP Signaling pathway

Answer 6

ANP
NO
EDRF (endothelium derived relaxation factor)

(Think vasodilators)

Question 7

IP3 signaling pathway

Gq and PLC

Answer 7

GOAT HAG

GnRH
Oxytocin
ADH (V1)
TRH
Histamine (H1)
Ang II
Gastrin

Question 8

Tyrosine Kinase receptors (intrinsic)

Answer 8

Insulin
IGF-1
FGF
PDGF
EGF

(Growth Factors)

Question 9

Tyrosine Kinase-Associated receptors

JAK/STAT

Answer 9

GH
Prolactin
Cytokines/Interleukins

(“-tins and -ters”)

Question 10

Tyrosine Kinase pathway

Answer 10

1. Receptor autophosphorylation
2. Activate GRB2
3. Activate SOS
4. Activate RAS
5. Downstream signaling (Raf-kinase, MAP-kinase)
6. Transcription factors

(Does NOT require another molecule for phosphorylation; “intrinsic”)

Question 11

Tyrosine kinase-associated receptor pathway

Answer 11

1. Tyrosine receptor dimerization
2. JAKs (tyrosine kinases) recruited
3. JAKs crossphosphorylate dimer
4. Activation/dimerization of STAT
5. Goes to nucleus and causes transcription

(*requires JAK for phosphorylation)

Question 12

Anterior Pituitary secretions

Answer 12

FSH
LH
ACTH
TSH
Prolactin
GH

(FLAT PiG)