Immunological drugs Flashcards

1
Q

Alemtuzumab

A

CD52

used in CLL

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2
Q

Muromonab

A

(OKT3)
CD3

immunosuppression in transplants

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3
Q

Natalizumab

A

alpha4-integrin

MS, Crohn

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4
Q

Rituximab

A

CD20

B-cell non-Hodgkin
CLL
RA
ITP

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5
Q

Cyclosporine

A

Cyclophilin - calcineurin inhibitor

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6
Q

Trastuzumab

A

HER2/neu

Breast cancer

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7
Q

Adalimumab

A

Soluble TNF-a

IBD
RA
ankylosing spondylitis
psoriasis

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8
Q

Sirolimus

A

FKBP-12
mTOR inhibitor

transplant

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9
Q

Tacrolimus

A

FKBP - calcineurin inhibitor

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10
Q

Abciximab

A

IIb/IIIa inhibitor

antiplatelet agent for PCI patients

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11
Q

Daclizumab

A

IL-2R

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12
Q

Omalizumab

A

IgE

Allergic asthma

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13
Q

Infliximab

A

Soluble TNF-a

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14
Q

Basiliximab

A

IL-2R

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15
Q

Ranibizumab

A

VEGF

neovascular age-related macular degeration

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16
Q

Denosumab

A

RANKL

Osteoporosis
inhibits osteoclast maturation

17
Q

Palivizumab

A

RSV F protein

RSV prophylaxis

18
Q

Bevacizmab

A

VEGF

CRC
renal cell ca

19
Q

Eculizumab

A

C5

PNH

20
Q

Azathioprine

A

blocks nucleic acid synthesis
purine metabolism

lupus nephritis

21
Q

Gluocorticoids target

A

NF-kB

22
Q

Etanercept

A

decoy TNF-a receptor (intercepts TNF-a)