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immunology > Immunology Lecture 1 > Flashcards

Immunology Lecture 1 Flashcards

1
Q

What is a TNF?

A

has inflammatory effects (primary mediator of septic shock which causes vascular damage)

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2
Q

Why do we want to block TNF?

A

reduce inflammation

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3
Q

What is the purpose of cytokines and interleukins?

A

regulate immune response

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4
Q

IL-1

A

made by macrophages, stimulates T cells, B cells, liver cells, etc

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5
Q

IL-2

A

produced by T cells - T cell growth factor (can also stimulate B cells and macrophages)

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6
Q

IL-3

A

CSF stimulator

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7
Q

What is CSF?

A

Colony stimulating factor (induce the growth of bone marrow derived cells and differentiation)

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8
Q

IL-4

A

B cell growth factor (important in T-cell stimulation of B-lymphocytes)

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9
Q

IL-5

A

B cell growth factor, B cell differentiation factor, and eosinophil growth factor

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10
Q

IL-6

A

principal mediator of the acute phase response of inflammation

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11
Q

IL-10

A

stimulates the induction of TH-2 cytokines

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12
Q

IL-12

A

stimulates TH1 responses

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13
Q

IL-17

A

involved in inflammation

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14
Q

What are inferferons??

A

interfere with viruses - non virally infected cells are protected from viruses - stimulate macrophages, T cell, B cells, NK cells

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15
Q

What is an NK cell?

A

lymphocyte - kills tumor cells and some virally infected cells without specificity

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16
Q

What is a cytotoxic T-cell?

A

regulation of the immune response (CD8) - antigen specific - restricted to killing cells that have self antigen in addition to foreign antigen

17
Q

What is a lymphocyte?

A

B and T cells

18
Q

What is a monocyte?

A

circulating precursor cell to macrophage

19
Q

What is a dendritic cell?

A

activation of T cells and initiation of adaptive immune response

20
Q

What is a mast cell?

A

expulsion of parasites through release of granules (esp histamine)

21
Q

What is a macrophage?

A

phagocytosis and killing of microorganisms - activation of T cells and initiation of immune responses

22
Q

What is a eosinophil?

A

killing of antibody-coated parasites through release of granule contents

23
Q

Where do monocytes come from?

A

bone marrow derived (called macrophages when enter tissues)

24
Q

What is a neutrophil?

A

phagocytosis and killing of microorganisms

25
Q

CD3

A

mature T cells

26
Q

CD4

A

T-helper

27
Q

CD8

A

T-cytotoxic

28
Q

CD28

A

recognition of presenting cells

29
Q

CD40

A

co-stimulatory molecule

30
Q

CD25

A

IL-2 receptor (high affinity)

31
Q

What is an opsonin? Give an example

A

something that increases phagocytosis by binding to the antigen - example: complement

immunology (18 decks)

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