G-protein-linked 2nd messengers

Question 1

alpha-1

Answer 1

Gq: increases [Ca2+]
Increases: vascular smooth muscle contraction, pupillary dilatory muscle contraction (mydriasis), intestinal and bladder sphincter muscle contraction

Question 2

alpha-2

Answer 2

Gi: decrease cAMP
Decreases: sympathetic outflow, insulin release, lipolysis,
Increases: platelet aggregation

Question 3

beta-1

Answer 3

Gs: increases cAMP
Increases: HR, contractility, renin rlease, lipolysis

Question 4

beta-2

Answer 4

Gs: increase cAMP
Vasodilation, bronchodilation, ciliary muscle relaxation
Increases: HR, contractility, lipolysis, insulin release, aqueious humor production
Decreases: uterine tone (tocolysis)

Question 5

M1

Answer 5

Gq: increases [Ca2+]

CNS, ENS, GI secretions

Question 6

M2

Answer 6

Gi: decrease cAMP
SA node: decrease HR (negative chronotropy)
AV node: decrease conduction velocity (negative dromotropy) and ventricular contraction

Question 7

M3

Answer 7

Gq: increases [Ca2+]
Increases: exocrine gland secretions (lacrimal, salivary, gastric acid), gut peristalsis, bladder contraction, bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)

Question 8

D1

Answer 8

Gs: increase cAMP

Relaxes renal vascular smooth muscle

Question 9

D2

Answer 9

Gi: decrease cAMP

Modulates transmitter release, especially in brain

Question 10

H1

Answer 10

Gq: increases [Ca2+]
Increases: nasal and bronchial mucus production, vascular permeability, contraction of bronchioles, pruritus, and pain

Question 11

H2

Answer 11

Gs: increase cAMP
Increases: gastric acid secretion

Question 12

V1

Answer 12

Gq: increases [Ca2+]
Increases: vascular smooth muscle contraction

Question 13

V2

Answer 13

Gs: increase cAMP
Increases: H2O permeability and reabsorption in collecting tubules of kidney