16/17 - General principles of cancer chemotherapy

Question 1

normal cells that also divide rapidly

Answer 1

bone marrow
intestinal crypts
hair follicles

Question 2

drug therapy given after primary treatment to decrease chances cancer will return

Answer 2

adjuvant therapy

Question 3

shrink tumor before surgical resection

Answer 3

neodjuvant therapy

Question 4

T or F: chemotherapeutic drugs kill a constant number of cancer cells

Answer 4

False

kill a constant proportion (first order kinetics)

Question 5

epithelial-mesenchymal transition

Answer 5

process by which cells lose adhesive properties and become motile

Question 6

cell cycle nonspecific drugs

Answer 6

all DNA alkylating drugs and most DNA intercalating drugs

*while cell cycle nonspecific drugs can damage cells in all phases of the cell cycle, replicating cells are still more susceptible to these drugs

Question 7

purines

Answer 7

adenine and guanine

Question 8

pyrmidines

Answer 8

thymine
cytosine
uracil

Question 9

purine base –> nucleoside –> nucleotide

Answer 9

base = purine
add sugar = nucleoside
add phosphate and sugar = nucleotide

w/ 2OH group = RNA
w/o 2OH group = DNA