General Anesthetics

Question 1

Higher lipid solubility

Answer 1

higher potency

Question 2

What is potency influenced by?

Answer 2

temp, age, rx

not sex, o2, ph, bp

Question 3

How does cardiac output affect inhalation anesthetics?

Answer 3

-increased cardiac output–>slower induction

Question 4

What is FA/FI?

Answer 4

End tidal/Inspired

Fa=is the brain partial pressue

Question 5

how do you increase speed of induction

Answer 5

increase delivery

Question 6

What are the three main factors that determine uptake into blood?

Answer 6

1. solubility
   - not soluble reaches equilibrium faster and blood compartment is smaller
2. partial pressure difference
   - partial pressure drives movement not concentration
3. cardiac output
   - decreased cardiac output faster

Question 7

Propofol

Answer 7

• sedation
• IPSP-GABA?
• decreased CMRO2 and ICP
• dilator
• respiratory depression

Question 8

Ketamine

Answer 8

• dissociative anesthesia-short procedures
• NMDA receptor antagonist
• increased CMRO2 and ICP
• *increased BP and heart rate
• *bronchodilator-keep breathing
• bad dreams, salivation, twitchy

Question 9

Ketamine

Answer 9

• dissociative anesthesia-short procedures
• NMDA receptor antagonist
• increased CMRO2 and ICP
• *increased BP and heart rate
• *bronchodilator-keep breathing
• bad dreams, salivation, twitchy

Question 10

etomidate

Answer 10

• GABA
• decreased CRO2
• constrictor
• *least cardiovascular side effects
• *adrenal supression