4.2 PV & PG Flashcards
1
Q
adverse drug event
A
injury occurs during treatment, not necessarily caused by drug itself
2
Q
type A ADR
A
predictable from known pharmacology of drug, high morbidity, low mortality
3
Q
type B ADR
A
idiosyncratic, bizarre, novel response cant be predicated from pharmacology, low morbidity, high mortality
4
Q
link PK to genetic variability
A
ADME
5
Q
link PD to genetic variability
A
receptors, ion channels, enzymes, DNA
6
Q
4P’s of pharmacogenetics
A
prediction+prevention
precise
personalised
participatory
7
Q
mechanism of action of warfarin
A
vit K antagonist so cant activate clotting factors nor recycle vit K, less clotting
