Bolded info for Nordgren drugs

Question 1

Positive effects of Nitrates/trites on cardiac O2 consumption:

Answer 1

decrease LV EDP

decrease preload

Question 2

NTG should not be given with which drugs due to synergistic hypotension:

Answer 2

phosphodiesterase type 5 inhibitors

Vardenafil (viagra, cialis, ect)

Question 3

Positive effects (with respect to angina) of Ca2+ channel blockers on cardiac O2 consumption:

Answer 3

increased coronary blood flow

decreased aortic diastolic pressure

decreased HR

decreased contractility

Question 4

Positive effects (with respect to angina) of Beta blockers on cardiac O2 demand:

Answer 4

decreased aortic diastolic pressure

decreased HR

decreased contractility

Question 5

most common cause of angina?

Answer 5

atherosclerosis

Question 6

Weak Beta blocker in Class IC?

Answer 6

Propafenone

Question 7

Class IC with SLOW UNBLOCKING KINETICS?

Answer 7

Flecainide

Question 8

Class IB with extra cardiac effect of significant chronic pain relief?

Answer 8

Mexiletine

Question 9

Class IB used for Vtach

NOT ADVISED FOR PROPHYLAXIS

Answer 9

Lidocaine

Question 10

Class IA

Loading dose NOT recommended

Answer 10

Disopyramide

Question 11

Class IA

Toxicity = induction of TORSADES

Answer 11

Quinidine

Question 12

Class IA

TORSADES + LUPUS-like syndrome

Answer 12

Procainamide

Question 13

Why is “state dependance” useful in antiarrhythmics”?

Answer 13

Drugs bind preferentially to:
Activated (phase 0)
Inactivated (phase 2) channels

bind poorly to rested channels

so. …work best in tachycardia (lots of activations and inactivations per unit time)
- significant loss of resting membrane potential (many inactivated channels

Question 14

Normal LV end systolic volume (Wigger’s):

Answer 14

60 mL

Question 15

Normal LV end diastolic volume (Wigger’s):

Answer 15

120 mL