Diseases of Infancy and Childhood Flashcards
Most common fetal viral infection.
CMV
Represent primary errors of morphogenesis in which there is an intrisically abnormal developmental process, commonly multifactorial but may be the result of a single gene chromosomal defect.
Malformations
Result from the secondary destruction of an organ or body region that was previously normal in developmen and arise from an extrinsic disturbance in morphogenesis.
Disruptions
Classic example of a disruption wherein there is rupture of amnion with resultant formation of bands that encircle, compress or attach to parts of the developing fetus.
Amniotic Bands
True / False
Disruptions are not heritable and are not associated with risk of recurrence in subsequent pregnancies.
True
Represent an extrinsic distrubance of development and are common problems affecting 2% of newborn infants to varying degrees.
Deformations
MC underlying factor responsible for deformations.
Uterine Constraint
Maternal Factors
First Pregnancy
Small Uterus
Bicornuate Uterus
Leiomyomas
Fetal / Placental Factors
Oligohydramnios
Multiple Fetuses
Abnormal Fetal Presentation
A cascade of anomalies triggered by one initiating aberration.
Sequelae
Decreased amniotic fluid
Oligohydramnios
Other term for oligohydramnios sequence.
Potter sequence
Classic phenotype in newborn infants with Potter sequence.
Flattened Facies
Positional Abnormalities of the Hands and Feet
Nodules in the amnion.
Amnion Nodosum
A constellation of congenital anomalies believed to be pathologically related and cannot be explained on the basis of single, localized, initiating defect.
Malformation Syndrome
Refers to the complete absence of an organ and its associated primordium.
Agenesis
Absence of an organ due to failure of growth of the existing primordium.
Aplasia
The absence of an opening usually of a hollow visceral organ such as the trachea and the intestine.
Atresia