Benzodiazepenes

Question 1

Common indications

Answer 1

1. Management of seizures and status epilepticus
2. Alcohol withdrawal
3. Sedation for interventional procedures
4. Short term treatment of severe anxiety
5. Short term treatment of severe insomnia

Question 2

Mechanism

Answer 2

Enhance binding of GABA to GABAa receptor, enhancing its inhibitory effect. Causes a widespread depressant effect on synaptic transmission

Question 3

Important adverse effects

Answer 3

Drowsiness, sedation and coma
Dependence
Abrupt cessation can cause withdrawal

Question 4

In which groups of patient should benzodiazepines be used carefully ?

Answer 4

Elderly- more susceptible to effects

Avoid in significant respiratory impairment, liver impairment, neuromuscular disease

Question 5

Example of a long-acting benzo. When would this be used?

Answer 5

Diazepam, lorazepam. Alcohol withdrawal

Question 6

Best drug to use for anxiety/insomnia

Answer 6

Intermediate acting benzo such as temazapam