Typhoid Fever

Question 1

Synonyms of Typhoid Fever

Answer 1

• Enteric Fever
• Salmonellosis
• Gastric Fever
• Pathogenic Fever

Question 2

Causative agent of typhoid fever

Answer 2

Salmonella typhi

Question 3

Non spore-forming, facultative anaerobic bacilli, motile, non-lactose forming; chemoorganotroph

Answer 3

Salmonella typhi

Question 4

Antigens of Salmonella typhi

Answer 4

O, H, Vi Antigens

Question 5

Severe gastroenteritis accompanied by a high fever

Answer 5

Typhoid

Question 6

Cause of typhus fever

Answer 6

Rickettsiae typhi (fleas)
Rickettsiae prowazekii (body lice)

Question 7

Family of salmonella typhi

Answer 7

Enterobacteriaceae

Question 8

Where does the typhoid organism pass through to reach the small intestine

Answer 8

Pylorus

Question 9

Salmonella typhi penetrates mucosal epithelium via:

Answer 9

• Microfold cells

* Enterocytes

Question 10

Where Samonella typhi elicit an influx of macrophages

Answer 10

Lamina propria

Question 11

Incubation period of Salmonella typhi

Answer 11

8-14 days

Question 12

Induce inflammatory reaction

Answer 12

Proinflammatory cytokines

Question 13

How typhoid pathogen penetrate the intestinal epithelium

Answer 13

Peyer’s Patches

Question 14

Virulence factor responsible for the multiplication of Salmonella

Answer 14

Invasins

Question 15

Virulence factor responsible for fever production of Salmonella

Answer 15

Lipid A Endotoxin

Question 16

Virulence factor that causes cellular invasion of intestinal cells; produce ulcers (by Salmonella)

Answer 16

Cytotoxins

Question 17

Virulence Factor that increases secretion of sodium

Answer 17

Heat-Stable Exotoxin

Question 18

Virulence Factor that increases secretion of Chloride

Answer 18

Heat-Labile Exotoxins

Question 19

Characteristic of stool of those infected w/ typhoid fever

Answer 19

Greenish Pea Soup

Question 20

Slow pulse

Answer 20

Dicrotic

Question 21

Rose Spots

Answer 21

Exanthem

Question 22

Signs and symptoms of Typhoid Fever

Answer 22

Rose Spots, Diarrhea, Splenomegaly

Question 23

Adults: Constipation or diarrhea

Answer 23

Constipation

Question 24

Most common method of diagnosis of Typhoid Fever

Answer 24

Blood Culture

Question 25

Detects agglutinating of antibodies against the O and H antigens of S. typhi

Answer 25

Widal Test

Question 26

Detects IgM to the 0:9 Antigen

Answer 26

IDL Tubex

Question 27

Detects both IgM and IgG

Answer 27

Typhidot Assay

Question 28

Major complications of Typhoid Fever

Answer 28

Intestinal Perforations

Intestinal Hemorrhage

Question 29

Two Vaccines for Typhoid Fever

Answer 29

Vi Polysaccharide

Live Oral Vaccine Ty21a

Question 30

Antigen that is a heat-labile flagella; protein structure

Answer 30

H Antigen

Question 31

Heat stable antigen; outer membrane; production of fever; somatic

Answer 31

O Antigen

Question 32

Outer shell envelope; inhibits phagocytosis by interfering w/ actions of complement systems; increase virulence

Answer 32

Vi Antigen

Question 33

4 Stages of Typhoid Fever:

Answer 33

• Temp Rising
• High Fever
• Complications
• Defervescence

Question 34

1st Drug of Choice for Typhoid Fever

Answer 34

Chloramphenicol

Question 35

Drug with the risk of irreversible bone marrow aplasia

Answer 35

Chloramphenicol

Question 36

Adjunctive therapy

Answer 36

Dexamethasone

Question 37

Drug that lowers the likelihood of relapse

Answer 37

Oral amoxicillin

Question 38

Other drugs (first-line of antibiotics)

Answer 38

Ampicillin, Trimethoprim-Sulfamethoxazole

Question 39

Spleen

Answer 39

Lymphoid Tissue