Antidepressants Flashcards

1
Q

Tranylcypromine

A
  • MAOI: irreversibly inhibit both MAOa and MAOb
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: hypertensive crisis (with tyramine), serotonin syndrome (MAOi+SSRI), agitation (rare), delerium, seizures, anticholinergic effects, orthostatic hypotension, sexual dysfunction, weight gain, sedation
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2
Q

Phenelzine

A
  • MAOI: irreversibly inhibit both MAOa and MAOb
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: hypertensive crisis (tyramine), serotonin syndrome (MAOI+SSRI), agitation (rare), delerium, seizures, anticholinergic effects, orthostatic hypotension, sexual dysfunction, weight gain, sedation
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3
Q

Desipramine

A
  • Tricyclic: block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: sympathomimetic (cardiac arrythmias and conduction defects), antimuscarinic effects, orthostatic hypotension, sedation, seizures
  • Rarely used
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4
Q

Imipramine

A
  • Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Rarely used
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5
Q

Amitriptyline

A
  • Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, prevention of tension headaches, migraines
  • Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Rarely used
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6
Q

Nortriptyline

A
  • Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Rarely used
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7
Q

Fluoxetine

A
  • SSRI: inhibit reuptake of 5-HT and NE to lesser extent
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder
  • Side effects: serotonin syndrome with MAOIs, nausea, decreased sexual function
  • Potent P450 inhibitor
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8
Q

Paroxetine

A
  • SSRI: inhibit reuptake of 5-HT and NE to a lesser extent
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: serotonin syndrome with MAOI, nausea, sexual dysfunction
  • Potent p450 inhibitor
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9
Q

Sertraline

A
  • SSRI: inhibit reuptake of 5-HT and NE to lesser extent
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: serotonin syndrome with MAOI, nausea, decreased sexual function
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10
Q

Escitalopram

A
  • SSRI: inhibit reuptake of 5-HT and NE to a lesser extent
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: serotonin sydrome with MAOIs, nausea, sexual dysfunction
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11
Q

Citalopram

A
  • SSRI: inhibit reuptake of 5-HT and NE to less extent
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • Side effects: serotonin syndrome with MAOIs, nausea, sexual dysfunction
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12
Q

Duloxetine

A
  • SNRI: inhibit reuptake of 5-HT and NE

- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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13
Q

Venlafaxine

A
  • SNRI: inhibits reuptake of 5-HT and NE

- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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14
Q

Bupropion

A
  • Atypical antidepressant: blocks DA and NE reuptake
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, maintain nicotine abstinence in quitting smokers
  • Side effects: lowers seizure threshold
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15
Q

Mirtazapine

A
  • Atypical antidepressant: 5HT2a antagonists, also inhibit 5HT reuptake
  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
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16
Q

Lithium

A
  • Unknown; lithium depletes secondary messengers IP3 and DAG, important in a-adrenergic and muscarinic-cholinergic transmission
  • Anti-manic/mood-stabilizing (bipolar), long term cluster headache prevention
  • Side effects: neurotoxicity, cardiac toxicity, renal dysfunction
  • Side effects: drowsiness, weight gain, tremor, polydipsia, polyuria, N/V