Antidepressants Flashcards
1
Q
Tranylcypromine
A
- MAOI: irreversibly inhibit both MAOa and MAOb
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: hypertensive crisis (with tyramine), serotonin syndrome (MAOi+SSRI), agitation (rare), delerium, seizures, anticholinergic effects, orthostatic hypotension, sexual dysfunction, weight gain, sedation
2
Q
Phenelzine
A
- MAOI: irreversibly inhibit both MAOa and MAOb
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: hypertensive crisis (tyramine), serotonin syndrome (MAOI+SSRI), agitation (rare), delerium, seizures, anticholinergic effects, orthostatic hypotension, sexual dysfunction, weight gain, sedation
3
Q
Desipramine
A
- Tricyclic: block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: sympathomimetic (cardiac arrythmias and conduction defects), antimuscarinic effects, orthostatic hypotension, sedation, seizures
- Rarely used
4
Q
Imipramine
A
- Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
- Rarely used
5
Q
Amitriptyline
A
- Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, prevention of tension headaches, migraines
- Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
- Rarely used
6
Q
Nortriptyline
A
- Tricyclic: Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD), Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
- Rarely used
7
Q
Fluoxetine
A
- SSRI: inhibit reuptake of 5-HT and NE to lesser extent
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder
- Side effects: serotonin syndrome with MAOIs, nausea, decreased sexual function
- Potent P450 inhibitor
8
Q
Paroxetine
A
- SSRI: inhibit reuptake of 5-HT and NE to a lesser extent
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: serotonin syndrome with MAOI, nausea, sexual dysfunction
- Potent p450 inhibitor
9
Q
Sertraline
A
- SSRI: inhibit reuptake of 5-HT and NE to lesser extent
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: serotonin syndrome with MAOI, nausea, decreased sexual function
10
Q
Escitalopram
A
- SSRI: inhibit reuptake of 5-HT and NE to a lesser extent
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: serotonin sydrome with MAOIs, nausea, sexual dysfunction
11
Q
Citalopram
A
- SSRI: inhibit reuptake of 5-HT and NE to less extent
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
- Side effects: serotonin syndrome with MAOIs, nausea, sexual dysfunction
12
Q
Duloxetine
A
- SNRI: inhibit reuptake of 5-HT and NE
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
13
Q
Venlafaxine
A
- SNRI: inhibits reuptake of 5-HT and NE
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
14
Q
Bupropion
A
- Atypical antidepressant: blocks DA and NE reuptake
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, maintain nicotine abstinence in quitting smokers
- Side effects: lowers seizure threshold
15
Q
Mirtazapine
A
- Atypical antidepressant: 5HT2a antagonists, also inhibit 5HT reuptake
- Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism