Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

VCF Pharm Unit 3 > Dopaminergic Drugs > Flashcards

Dopaminergic Drugs Flashcards

1
Q

Levodopa

A
  • DA precursor: crosses BBB and is converted to DA
  • Given with carbidopa for parkinson’s unless pt is young
  • Side effects: dyskinesias, hypotension, nausea, anxiety, fatigue, psychoses
  • MAOA inhibitors are contraindicated
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carbidopa

A
  • AAAD inhibitor: inhibits peripheral conversion of L-DOPA into DA, does not cross BBB
  • Given with levodopa in parkinson’s
  • Side effects: dyskinesias, on-off phenomenon
  • MAOA inhibitors are contraindicated
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Buproprion

A
  • Norepi-DA reuptake inhibitor: NRDI: Blocks DAT to increase DA in synapse
  • Parkinson’s, depression
  • Side effects: insomnia, anxiety, agitation, nausea, dry mouth, sweating, palpitations, mild increase in BP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

dextroamphetamine; lisdexamfetamine

A
  • Stimulant: blocks DAT and increases VMAT2
  • ADHD
  • NE and DA side effects, weight loss, addictive, psychosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Modafinil; Armodafinil

A
  • Stimulant: increases histamine activity at the tuberomamillary nucleus, may block DAT
  • Side effects: fatigue, narcolepsy, apnea, addiction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Selegiline

A
  • MAO-B inhibitor: prevents breakdown of DA
  • Early parkinson’s, depression
  • Side effects: hypotension, dizziness, insomnia, weight gain, N/V
  • Comes in patch form for depression:EMSAM
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rasagiline

A
  • MAO-B inhibitor: prevents breakdown of DA
  • Early parkinson’s
  • Side effects: hypotension, dizziness, insomnia, weight gain, N/V
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Tranylcypromine (Parnate); Isocarboxazid (Marplan); Phenelzine (Nardil)

A
  • MAOI: irreversibly inhibit both MAO-A and MAO-B
  • Depression
  • Side effects: hypotension, dizziness, insomnia, weight gain, hypertensive crisis (tyramine), serotonin syndrome (MAOI+SSRI)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Entacapone

A
  • COMT inhibitor:prevents breakdown of DA
  • Parkinson’s
  • Side effects: nausea, fatigue, DA side effects
  • Short acting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tolcapone

A
  • COMT inhibitor: prevents breakdown of DA
  • Parkinson’s
  • Nausea, fatigue, liver failure, DA side effects
  • Only use if entacapone fails
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Bromocriptine

A
  • Ergot D2 receptor agonist: Increase DA activity
  • Mild parkinson’s, RLS, hyperprolactinemia
  • Side effects: mania, nausea, dizziness, fatigue, peripheral DA effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pramipexole; ropinerole

A
  • Selective D2 receptor agonist, increases DA activity
  • Mild parkinson’s, RLS
  • Side effects: mania, nausea, dizziness, fatigue, peripheral DA-effect
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Apomorphine

A
  • D2 receptor agonist, increases DA activity
  • Mild parkinson’s, RLS
  • Side effects: mania, nausea, dizziness, fatigue, peripheral DA effects
  • Injectable only
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aripiprazole

A
  • D2 and D3 receptor (parial) agonist, increases DA activity
  • Schizophrenia, depression
  • Side effects:akathisia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Amantadine

A
  • Antiviral: stimulates D2 receptors, blocks DAT (?)
  • Mild parkinson’s, influenza
  • Side effects: nausea, dizziness, psychosis, insomnia, seizures
  • Contraindicated in elderly with dementia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Reserpine

A
  • Synapse depleter: blocks VMAT
  • Hypertension
  • Side effects: depression
17
Q

Tetrabenazine

A
  • Synapse depleter: blocks VMAT
  • Huntington’s
  • Side effects: depression
18
Q

Benztropine; trihexiphenidyl

A
  • Anticholinergics: antagonize ACh muscarinic receptor
  • Early parkinson’s, reduce EPS parkinsonian side effects
  • Side effects: typical anticholinergic effects
  • Contraindicated in demented parkinson’s
19
Q

Diphenhydramine

A
  • Antihistamine: anticholinergic properties
  • Reduce EPS parkinsonian side effects
  • Side effects: typical anticholinergic
20
Q

Chlorpromazine; thioridazine

A
  • First gen antipsychotic (low potency): non-selective D2 receptor antagonism
  • Psychosis, schizophenia,
  • Side effects: EPS, fatigue, weight gain, anticholinergic effects, orthostasis, tardive dyskinesia
  • Little effect on negative symptoms
21
Q

Fluphenazine; thiothixine; haloperidol

A
  • First gen antipsychotic (high potency): non-selective D2 receptor antagonism
  • Psychosis, schizophrenia, movement disorder in Huntingtons
  • Side effects: EPS, NMS, tardive dyskinesia
  • Little effect on negative symptoms
22
Q

Clozapine

A
  • Second gen antipsychotic: D2 (D1, D4) receptor antagonist, 5HT2a receptor antagonist
  • Refractory schizophrenia
  • Side effects: agranulocytosis
23
Q

Olanzapine; quetiapine; asenapine

A
  • Second gen antipsychotics: D2 receptor antagonist, 5HT2a receptor antagonist
  • Psychosis, mania, aggression
  • Side effects: suicide risk in ages
24
Q

Risperidone; ziprazidone; paliperidone; iloperidone, lurasidone

A
  • Second gen antipsychotic: D2 receptor antagonist but various other receptor agonism/antagonism
  • Psychosis, mania, aggression
  • Side effects: suicide risk in

VCF Pharm Unit 3 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions