Neurology # 3 Flashcards
MCA area of lesion
motor cortex - upper limb and face
Sensory cortex - upper limb and face
temporal lobe (wernicke area); frontal lobe (broca area)
ACA area of lesion
motor cortex - lower
sensory cortex - lower limb
Lenticulo-striate artery
striatum, internal capsule
Neurofibromatosis type 1 (von recklinghausen disease)
neurocutaneous disorder characterized by cafe-au-lait spots, cutaneous neurofibromas, optic gliomas, Lish nodules (pigmented iris hamartomas)caused by mutation in the NF1 gene on chormosome 17
How is labor pain controlled?
pudendal nerve blocks for perineal pain
What is malignant hyperthermia? Treatment?
Rare complication of anesthetic use during surgery. An excessive increase in cytosolic calcium leads to a depletion of intracellular ATP. Oxygen consumption is increased in an attempt to resupply ATP and this leads to the increased production of heat and carbon dioxide as byproducts. This produces symtoms of rhabdomyolyolysis, muscle spasm and lactic acidosis. Treatment: dantrolene
CN III palsy
eye looks down and out; ptosis, pupillary dilation, loss of accommodation
CN IV damage
eye moves upward, particularly with contralateral gaze and head tilt toward the side of the lesion
CN VI damage
medially directed eye that cannot abduct
Fabry’s Disease findings
Peripheral neuropathy of hands / feet, angiokeratomas, cardiovascular / renal disease
Fabry’s Disease deficient enzyme, accumulate substrate, inheritance
alpha-galactosidase A. ceramide trihexoside. X-linked recessive.
Carbamazepine mechanism and side effects
increases sodium channel inactivation. Diplopia, ataxia, blood dyscrasias (agranulocytosis,a aplastic anemia), liver toxicity, teratogenesis, induction of cytochrome P-450, SIADH, Stevens-Johnson syndrome
