Principles of Leukopenia and Leukocytosis

Question 1

leukopenia

Answer 1

=decrease WBC
* neutropenia: CTX, severe infection
TX: CM-CSF, or G-CSF
* Lymphopenia: DiGeorge, no fxnl thymus, high cortisol, SLE, radiation

Question 2

leukocytosis

Answer 2

= increase WBC

• Neutrophilic leukocytosis
• monocytosis
• Eosinophilia
• Basophilia
• Lymphocytic leukocytosis
• Infectious mononucleosis

Question 3

normal WBC count

Answer 3

5-10K

Question 4

neutrophilic leukocytosis

Answer 4

D/t bacterial infection or tissue necrosis
left shift
decrease FcR and CD16+
high cortisol disrupts margination

Question 5

monocytosis

Answer 5

chronic inflammatory state, bacterial endocarditis, rickettsiosis, malaria, autoimmune, IBD
malignancy

Question 6

eosinophlia

Answer 6

allergic rxns
parasitic infection - helminthic
HL - IL-5 production

Question 7

basophilia

Answer 7

ax w/ CML, myeloproliferative dz

Question 8

lymphocytic leukocytosis

Answer 8

viral infections, chronic immunologic stim

Bordatella pertussis

Question 9

infectious mononucleosis

Answer 9

reactive T-cells
EBV infection–> lymphocytic leukocytosis comprised of reactive CD8+ T cells
EBC –> hyperplasia of paracortex
splenomegaly, periarterial lymphatic sheath of WHITE pulp
Monospot test(+)
if (-) –> CMV