Chronic Regional Pain Syndrome

Question 1

Epidemiology of CRPS?

Answer 1

F3:M1
type 1 5 in 100000
type 2 0.8 in 100000

Question 2

Aetiology CRPS

Answer 2

type 1 - due to soft tissue injury

type 2 - damage to nerves (ie amputation

Question 3

Pathogenesis of CRPS

Answer 3

peripheral nerve noiceptions = central sensitisaion = pain/inflam
increased SNS - vasoconstriction/swelling

Question 4

Natural History of CRPS

Answer 4

remit or remain stable for years but may progess and spread

Question 5

Manefestations of CRPS

Answer 5

autonomic changes (sweating/vasomotor abnormal)
motor changes (weakness dystonia)
trophic changes - skin/bone atrophy/hair loss/jt contracture

Question 6

Symptoms of CRPS?

Answer 6

pain (burning/itching)
motor weakness
tremors
spasms
dystonia
distress

Question 7

signs of CRPS

Answer 7

allodynia
hyperalgesia
oedema
contractures
vaso changes (temperature,colour)
trophic (dry skin,hair loss).

Question 8

Complications

Answer 8

permanent neurological changes
skin bone changes
decrease ROM of limbs

Question 9

Prognosis

Answer 9

complete spontaneous relief with 80 % of type 1