malpractice in medicine

Question 1

name some ways trials can play design games

Answer 1

by choosing an obscure comparator
comparator with wrong dose
choosing outcomes that inflate effects
avoiding active comparators

Question 2

name some ways trials can play analysis games

Answer 2

making plans up as go along
torture the data using lots of different tests
use subgroups to show significance
using percentage relative change
testing the wrong things
avoiding intention to treat
changing your primary outcomes to the one that looks best
ignoring baseline differences
stopping the trial early when have positive results

Question 3

name some ways trials can play write up games

Answer 3

mechanism smoke screen
misinterpreting stuff with equivalence 
avoid mentioning side effects
inflating scales
using positive language (framing bias)
selective reporting bias

Question 4

name some ways trials can play publishing games

Answer 4

dont/delay publish neg studies
publishing in obscure journals
salami publishing
duplicate publishing