Autonomic Pharmacology of Resp System

Question 1

β₂ substrates

Answer 1

isoproterenol > epi >> NE

Question 2

α₁ receptor

stimulatory molecules

Answer 2

epi = NE >> isoproterenol

Question 3

nAChR

parasympathetics

location and function

Answer 3

post-synaptic surface of pre-ganglionic

leads to activation of postganglionic nerve

via Na⁺ channel → depolarization

Question 4

α₁ in lungs

Answer 4

not present in bronchial sm muscle

Question 5

α₁ status of bronchioles

Answer 5

α₁ not found in bronchioles

Question 6

Pulmonary toxicity of β-blockers

Answer 6

bronchoconstriction

Question 7

Phenylephrine

MOA

TU

Answer 7

MOA: α₁ agonist

TU: decongestant

Question 8

Terazosin

MOA

Pulmonary effects

Answer 8

MOA: α₁ antagonist

PE: mucosal congestion

Question 9

ACEI cough

Answer 9

ACE normally breaks down kinins

kinins cause angioedema

cough

Question 10

Tiotropium

MOA

Pulmonary effects

Answer 10

MOA: mAChR antagonist

PE: bronchodilator

Question 11

mAChR

parasympathetic

location

function

mechanism

Answer 11

on end organs

activates phospholipase C or suppresses adenylyl cyclase

Question 12

Varenicline

MOA

TU

Answer 12

MOA: nAChR agonist

TU: smoking cessation

Question 13

Guanethidine

MOA

Pulmonary effects

Answer 13

MOA: NE-depleting

PE: mucosal congestion

Question 14

Ipratorpium

MOA

Pulmonary effects

Answer 14

MOA: mAChR antagonist

PE: bronchodilator

Question 15

α₁ mechanism

Answer 15

stimulation of phospholipase C

IP₃

elevate intracellular Ca²⁺ levels

Question 16

Bethanecol

MOA

Pulmonary Effects

Answer 16

MOA: mAChR agonist

PE: bronchoconstriction

Question 17

Ephedrine

MOA

TU

Answer 17

MOA: activates release of NE + has direct effects

TU: nasal decongestion, Adams-Stokes syndrome, bronchospasm