Antifungals that target inhibition of of ergosterol synthesis Flashcards
1
Q
What drugs target ergosterol synthesis thru squalene epoxidase inhibition?
A
Naftifine and Terbinafine (lamisil)
2
Q
what are naftitine and terbinafine used for?
MoA
A
used in tx of skin and nail infections
synthetic compounds that inhibits 1st step in ergosterol synthesis causing squalene to accumulate
3
Q
The inhibition of squalene epoxidase by what 2 drugs is static or tidal?
A
naftitine and terbinafine cause inhibition of squalene epoxidase which is fungiCIDAL
4
Q
what is the selectivity of naftitine and terbinafine?
A
host squalene epoxidases are much less affected
5
Q
how are naftitine and terbinafine used and for what>
A
topical for dermatophytes
Terbinafine can be oral
6
Q
describe the tx of terbinafine
A
90 tx, with potential liver toxicity so must test liver function!
