Shnyra - Immuno Path of IBD Flashcards
1
Q
major innume mechanism of the GI system
A
exclusion
2
Q
spontaneous colitis doesn’t occur in what kind of mouse strains?
A
raised in germ-free environment
3
Q
suppression of NF-kappaB pathway
A
commensal microflora
4
Q
mechanism of IBD WRT MPs
A
“tolerance” to GI microflora is lost and thus MPs secrete pro-inflammatory cytokines
5
Q
bact what trigger UC
A
aerobic bact
6
Q
bact that trigger CD
A
anaerobic bact
7
Q
ASCA +
A
Crohns
8
Q
pANCA +
A
UC
9
Q
Th1 and Th17 > IL-17 and INF-gamma - type IBD
A
Crohns
10
Q
Th2 > IL-5 and IL-4 - type IBD
A
UC
11
Q
IL produces by APCs
A
IL-23
12
Q
greatest genetic risk of IBD
A
first-deg relatives
