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GI > cancer treatments > Flashcards

cancer treatments Flashcards

1
Q

how does bevacizumab work? what GI cancer is it used for?

A

anti-VEGF

colorectal cancer

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2
Q

what does cetuximab do? what is it used for?

A

anti-EGFR

colorectal cancer

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3
Q

what does erlotinib do? what is it used for?

A

EGFR TKI

pancreatic cancer

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4
Q

what is the use of glutamic acid?

A

supplement deficiencies of HCl in gastric juice in gastric cancer

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5
Q

what does imatinib do? what is it used for?

A

c-KIT TKI (+ others)

GIST

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6
Q

what is leucovorin? what does it do?

A 
folinic acid (reduced folate)
drive incorporation of 5-FU into intermediary metabolism, increasing the drug's effectiveness
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7
Q

what does methysergide do? what is it used for?

A

serotonin inhibitor in GI tract

GI neuroendocrine tumors

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8
Q

what is ocreotide? what cancer is it used for?

A

somatostatin analog

GI neuroendocrine tumors

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9
Q

what does sorafenib do? what is it used for?

A

PDGFR, c-KIT, and RET TKI

HCC

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10
Q

what does sunitinib do? what is it used for?

A

PDGFR, VEGFR, c-KIT, and RET TKI

GIST

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11
Q

what does trastuzumab do? what is it used for?

A

anti-HER-2/neu

gastric cancer

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12
Q

what targeted drugs are used to treat colorectal cancer? when can’t they be used? what are two cytotoxic therapies used?

A

bevacizumab and cetuximab: don’t use with KRAS mutations

FOLFOX and FOLFIRI

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13
Q

what two cytotoxic drugs are used in most treatments of esophageal, anal, and gastric cancers?

A

cisplatin and 5-FU

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14
Q

what non-cytotoxic drugs are used in gastric cancer?

A

trastuzumab

glutamic acid

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15
Q

what non-cytotoxic drugs are used for neuroendocrine tumors?

A

octreotide
methysergide
IFN-alpha

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16
Q

what is first and second line treatment of GISTs?

A

1st: imatinib
2nd: sunitinib

17
Q

what two regimens are used for pancreatic cancer?

A

gemcitabine+/-erlotinib

FOLFIRINOX: 5-FU, leucovorin, irinotecan, oxaplatin

18
Q

what is the advantage of trans-catheter arterial chemoembolization and what drug is used?

A

doxorubicin

-spares normal tissue, minimizes dispersion of drug away from target site

19
Q

what drug is considered standard of care for HCC?

A

sorafenib

GI (5 decks)

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