Drugs and the Heart Flashcards
When the heart is temporarily deprived of oxygen it causes…
Angina
When the heart rhythm is disturbed it is known as…
Dysrhythmia
When the heart is deprived of oxygen for a long time what happens?
Heart attack
When the heart does not pump properly it causes
Heart failure
Treatment for angina
Reduce oxygen demand
Increase oxygen supply and blood flow.
What do you know about Glyceryl trinitrate (GTN) and propranolol?
Dilate peripheral blood vessels so :
- the heart doesn’t have to work as hard
- Less blood returned to heart
- Treatment for angina and heart attack
What do you know about Atenolol?
A beta blocker
Acts of beta 1 receptors in the heart.
What does ischaemia lead to?
Muscle death
What do you know about Digoxin?
Acts on the heart to increase cardiac output.
Increase the force of contraction without increasing oxygen consumption.
Inhibit Na+/K+ ATPase
Increase Ca2+
Targets for antidysrhythmic drugs
Sodium channels
Beta 1 adrenoceptors
Potassium channels
Calcium channels
Antidysrhythmic drugs targeting sodium channels
Lidocaine
Flecainide
Diisopyraminde
Antidysrhythmic drugs targeting beta 1 adrenoceptors
Atenolol
Metoprolol
Propanolol
Antidysrhythmic drugs targeting potassium channels
Amiodarone
Sotaolol
Antidysrhythmic drugs targeting calcium channels
Verapamil
Diltiazem
