receptor superfamilies and signal transduction mechanisms Flashcards
What is an agonist?
an agent that binds a receptor and produces a signal
what must happen for a receptor to produce a signal?
it must be stimulated by am agonist?
what is primary agonist?
a drug binds to the same recognition site as the endogenous agonist
What is a anagonist?
An agent that binds a receptor and prevents the agonist to produce an effect
What are the four superfamilies of receptors?
Ionotropic receptors
metabotropic receptors
Enzyme linked receptors
intracellular receptors
What are metabotropic receptors?
receptors connected to G proteins
Which events does ionotropic receptors control?
the fastest synaptic events in the nervous system
What is the ion conductance controled by in ionotophic receptors?
ligand binding (ligand gated) Voltage change (voltage gated) secondary messenger regulated
What is the function of Gproteins?
couple stimulation of receptors
What are characteristics of g proteins?
alpha, beta. gamma receptors
seven trasnsmembrane helices
4 intracellular and extracellular domains
What type of signals use enzyme linked receptors?
Growth factors
insulin
cytokines
What receptors or often enzyme linked receptors?
tyrosine kinases
tyrosine phosphotase
they dimerize upon activation
Where are intracellular receptors?
mobile receptors that are soluble constituents of the cytosol
What the types of intracellular receptors?
Type 1
type 2
Where type 1 intracellular receptor found?
in cytosol
used for sex hormones
glucocorticoids
mineralocorticoids
