Chapter 4 Lecture 9-11

Question 1

Which of the following is a transcription factor?

A. FGF

B. Pax

C. TGF

D. Notch

E. Wnt

Answer 1

B. Pax

Question 2

A mutation of what receptor is the basis for basal carcinomas of the skin?

A. Patched

B. Retinoic acid

C. Notch

D. FGF receptor

E. None of the above

Answer 2

A. Patched

Question 3

Zinc fingers or helix loop helix arrangement are characteristic of members of what class of molecules?

A. Proto-oncogenes

B. Signaling molecules

C. Receptors

D. Transcription factors

E. None of the above

Answer 3

D. Transcription factors

Question 4

Based on your knowledge of paralogous groups, which gene would be expressed most anteriorly in the embryo?

A. Hoxa-13

B. Hoxc-9

C. Hoxd-13

D. Hoxb-1

E. Hoxb-6

Answer 4

D. Hoxb-1

Question 5

Sonic hedgehog is produced in which signaling center?

A. Notochord

B. Intestinal portals

C. Floor plate of neural tube

D. Zone of polarizing activity in the limb bud

E. All of the above

Answer 5

E. All of the above

Question 6

Where in the cell is the retinoic acid receptor located?

Answer 6

In contrast to many receptors, the receptors for retinoic acid (alpha, beta and gamma) are located in the nucleus.

Question 7

What is a homeobox?

Answer 7

A highly conserved region consisting of 180 nucleotides that is found in many morphogenetically active genes. Homeobox gene products act as transcription factors.