Female Repro

Question 1

Theca Cells

Answer 1

androgen production

LH –> androtensidion >> testosterone

• The theca cell layers (externa and interna are vascularized
• NO FSH receptors

Question 2

Preovulatory Granulosa Cells

Answer 2

ovarian estrogen production

FSH –> secreted estrogens E2 >> E1

Question 3

Granulosa Lutin Cells

Answer 3

Ovarian Progesterone Production

LH –> P4 >> E2

Question 4

Which ovarian cells respond to LH?

Answer 4

• Theca cells
• Granulosa Lutein Cells

Question 5

Which ovarian cells respond to FSH?

Answer 5

Preovulatory Grandulosa Cells

Question 6

11Beta-HSD2

Answer 6

Enzyme converting cortisol into cortisone

Question 7

LH

Answer 7

Luteinizing hormone

• stimulates theca cell and GC steroidogenesis
• causes the changes in GC function and cytoarchitecture to enable ovulation
• stimulates luteinization: the terminal differentiation of GC and theca cells

POST OVULATION: LH stimulates the luteinized GC and teca cells within the corpus luteum to produce and secrete appreciable amounts of progesterone and estrogens

Question 8

FSH

Answer 8

enables GC to convert aromatizable androgens (androstenedione and testosterone) into estrogens

• stimulates steriodogenesis in GC
• regulates GC mitosis during follicular growth (folliculogenesis)
• cAMP/PKA dependent

Question 9

Clomiphene citrate

Answer 9

• selective estrogen receptor modulator
• ERalpha antagonist within hypothalamus
• releases GnRH from fb inhibition by E2
• Short term effect: GnRH antagaonist

Question 10

luprolide acetate

Answer 10

GnRH agonist

Question 11

hCG

Answer 11

• LH-like bioactivity
• binds to LH receptor and stimulates the corpus luteum to continue producing progesterone