Types of Toxophoric Groups

Question 1

EWG (electron withdrawing group)

Answer 1

Michael acceptor; electrophilic group that can alkylate biological nucleophiles, for example cysteine

Question 2

Epoxide

Answer 2

electrophilic group that can alkylate biological nucleophiles

Question 3

Imidazole

Answer 3

can chelate metals, for example iron in heme proteins such as cytochrome P450 enzymes

Question 4

Furans and Thiophenes

Answer 4

tend to be metabolized to electrophilic epoxides

Question 5

Thioamides and Thioureas

Answer 5

tend to be metabolized to electrophilic imines

Question 6

Anilines

Answer 6

tend to be metabolized to electrophilic nitroso or quinone derivatives