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D&T 4 exam 1 > Ovarian disease > Flashcards

Ovarian disease Flashcards

1
Q

where do cystic follicle originate

A

unruptured graafian follicles or

follicles that ruptured and then sealed

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2
Q

What is luteal cyst lined with and what does it secrete? what happens when ruptured

A

luteinized granulosa cells
progesterone
peritoneal reaction

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3
Q

Stein-Levanthall syndrome

A

polycystic ovaries

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4
Q

Stein-Levanthall syndrome impact on insulin

A

insulin resistance

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5
Q

classification of ovarian tumors

A

surface epithelium
germ cells
sex cord - stroma

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6
Q

what is thought to give rise to epithelial neoplasia

A

cortical inclusions cysts

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7
Q

when do benign/boderline and malignant serous tumor occur

A

benign/boderline: younger

malignant: older

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8
Q

serous tumor gros presentation? bilateral or unilateral?

A

smooth-walled cyst
cyst with papillary excrescences
bilateral

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9
Q

histo for serous tumor

A

ciliated columnar cells

intercalted cell

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10
Q

is there invasion of boderline serous tumor

A

no

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11
Q

gross for malignant serous cystadenocarcinoma

A

more solid

invasion of ovarian stroma

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12
Q

histo for malignant serous cystadenoma

A

psammoma bodies

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13
Q

who gets mucinous tumors

A

middle age

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14
Q

which in more common mucinous or serous

A

serous

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15
Q

histo for mucinous benign

A

tall columnar cells with apical mucin

no cilia

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16
Q

what does benign mucinous resemble

A

cervix or intestines

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17
Q

gross for benign mucinous

A

multiloculated with tenacious mucous

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18
Q

histo for boderline mucinous tumor

A

complex glandular structures with nuclear atypia

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19
Q

what does malignant mucinous cystadenoma resemble? benign

A

malignant: intestinal epithelium
benign: cervical epithelium

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20
Q

what is pseudomyxomatous peritonei

A

extensive mucinous ascites

epithelial implants and adhesions

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21
Q

what other organ should be considered for pseudomyxomatous peritonei

A

appendix

22
Q

what is an aggressive variant endometrioid adenocarcinoma

A

clear cell adenocarcinoma

23
Q

what is cystadenofibroma? what is epithelium

A

benign fibrous stroma

- endometrioid, serous, mucinous or transitional

24
Q

What is brenner Tumor

A

Epithelial component is transitional (bladder)

benign

25
Q

epithelial tumors extend beyond ovary what can happen

A

peritoneal seeding with massive ascites filled with malignant cells

26
Q

tumor marker for epithelial cells? prognosis?

A

CA-125

poor prognosis

27
Q

how can you help with epithelial prevention

A

fallopian tube ligation
oral contraceptive therapy
BRCA mutations

28
Q

germ cell tumors are equivalent to what in males

A

testicular germ cells

29
Q

another name for germ cell tumor, benign teratomas

A

dermoid cyst

30
Q

who gets germ cell tumor, benign teratomas

A

young women

31
Q

germ cell tumor, benign teratomas is dervied from what

A

ectodermal

3 germ layers

32
Q

chromosome for germ cell tumor, benign teratomas

A

46 XX

33
Q

Immature/malignant teratomas tissue resembles what

A

same found in fetus or embryo

34
Q

how is treated

A

chemotherapy

35
Q

Immature/malignant teratomas gross apperace

A

smooth capsule
predominantly solid
necrosis/hemorrhage

36
Q

Monodermal teratomas

A

struma ovarii ( thyroid)

37
Q

Dysgerminoma? who gets it

A

childhood and young adults

gonadal dysgenesis

38
Q

Dysgerminoma secretes what hormone

A

hCG

39
Q

dysgerminoma histo

A

large vesicular cells with clear cytoplasm
well-defined cell borders
fibrous stroma containing lymphocytes

40
Q

Dysgerminoma treatement

A

radiotherapy

41
Q

what is endodermal sinus tumor

A

extraembryonic yolk sac structure

42
Q

what are markers in endodermal sinus tumor

A

alpha-fetoprotein

alpha-1-antitrypsin

43
Q

endodermal sinus tumor prognosis and treatement

A

bad

chemotherapy

44
Q

sex cord: granulosa-theca tumor what does it secrete

A

secretes estrogen and inhibin

45
Q

sex cord: granulosa-theca tumor gross

A

yellow due to lipid

46
Q

sex cord: granulosa-theca tumor histo

A

granulosal: call-exner bodies, sheets, strands
thecal: clusters or sheets of cuboidal to polygonal cells

47
Q

sex cord: fibroma-thecoma

A

fibroblast or plump spindle cells with lipid droplets

48
Q

sex cord: fibroma-thecoma hist

A

increased nuclear/cytoplasmic ratio

FIBROSARCOMAS

49
Q

sex cord: fibroma-thecoma associated with what syndrome

A

basal cell nevus

50
Q

what is Meigs syndrome

A

pelvic pain
mass
ascites
hydrothorax

fibroma-thecoma

51
Q

most common tumor metastatic tumor to ovary

A

Kruckenberg tumor

D&T 4 exam 1 (17 decks)

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