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Microbiology 2nd Sem Finals > Rhabdovirus > Flashcards

Rhabdovirus Flashcards

1
Q

Structure

A

Envelope
Peplomers spikes
Single stranded negative sense RNA
RNA dependent RNA polymerase

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2
Q

Peplomers spikes composed of

A

Viral glycoprotein

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3
Q

Inside the envelope

A

Ribonuceocaspid

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4
Q

Belong to the genus

A

Lyssavirus

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5
Q

Survives storage at

A

4 degree C weeks

-70 degree C years

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6
Q

Killed rapidly by

A

UV light
Heat
Lipid solvent
Trypsin detergents

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7
Q

Virus attaches to cells via

A

Glycoprotein spikes

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8
Q

Receptor

A

Nicotinic acethylcholine receptor

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9
Q

How many RNA species

A

5

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10
Q

Template for transcription is the genome RNA in the form of

A

Ribonucleoprotein RNP

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11
Q

Monocistronic mRNAs for five virions proteins

A

Nucleocapsid
Polymerase proteins
Matrix
Glycoproteins

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12
Q

Required replication

A

Viral N and P

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13
Q

Particles acquire an envelope by budding through the

A

Plasma membrane

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14
Q

Inner side of the envelope

A

Viral matrix

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15
Q

Outer side of the envelope that form spikes

A

Viral glycoprotein

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16
Q

Intermediate susceptibility include

A

Skunks
Raccoons
Bats

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17
Q

Recovery from infection is rare except

A

Certain bats

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18
Q

May transmit virus for months without showing any signs of disease

A

Vampire bats

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19
Q

Street virus long incubation period

A

21-60 days in dogs

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20
Q

Fixed or mutant virus multiplies rapidly, and the incubation period is shortened

A

4-6 days

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21
Q

Serotype

A

Single

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22
Q

Major factor in rabies virus neuroinvasiveness and pathology icily

A

G- glycoprotein

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23
Q

Substitution at amino acid _________ of the glycoprotein results in loss of virulence

A

Positon 333

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24
Q

Used in diagnostic immuno fluorescence for rabies

A

Antiserum prepared against the purified nucleocapsid

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25
Q

Virus multiplies at the

A

Site of inoculation

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26
Q

Possible enter the nervous system directly without

A

Local replication

27
Q

Multiplies in the central nervous system then develop

A

Encephalitis

28
Q

Organ with the highest titers of virus is the

A

Submaxillary salivary

29
Q

Shorter incubation period bite in

A

Face

30
Q

Pathognomonic sign

A

Negri bodies

31
Q

2-10 days, may show any of the following nonspecific symptoms

A

Short Prodromal phase

32
Q

2-7 days, patients show signs of nervous system dysfunction, hydrophobia or aerophobia

A

Acute neurologic phase

33
Q

Last phase lead to death

A

Coma

34
Q

Major cause of death

A

Cardiorespiratory arrest

35
Q

Paralytic rabies

A

Bat rabies virus

36
Q

Incubation period in dogs

A

3-8 weeks but it may be as short as 10 days

37
Q

Grown in the MRC -5 human diploid cell line

A

Human diploid cell vaccine

38
Q

Ultrafiltration and activated with b propiolactone

A

Human diploid cell vaccine

39
Q

No serious anaphylactic or encephalitic reactions have been reported

A

Human diploid cell vaccine

40
Q

Flury LEP
Chicken fibroblast
B- propiolactone
Zonal centrifugation

A

Purified chick embryo cell vaccine

41
Q

Fetal Rhesus monkey lung cells
Beta propiolactone
Aluminum phosphate

A

Rabies vaccine, adsorbed

42
Q

Made from infected sheep, goat or mouse brains

It causes sensitization to nerve tissue and results in postvaccinal encephalitis

A

Nerve tissue vaccine

43
Q

Developed to minimize the problem of postvaccinal encephalitis

A

Duck embryo vaccine

44
Q

Used for animals but not for human

A

Live attenuated viruses

45
Q

Types of rabies antibody

Gamma globulin prepared by cold ethanol fractionation from the plasma of hyper immunized humans

A

Rabies immune globulin, human (HRI G)

46
Q

Types of rabies antibody

Concentrated serum from horses hyper immunized with rabies virus
It has been used in countries where HRIG is not available

A

Anti rabies serum, equine

47
Q

The goal is to attain an antibody level presumed to be protective by means of vaccine administration prior to any exposure

A

Pre exposure prophylaxis

48
Q

Most common cause of death

A

10th

49
Q

Children age

A

5-15

50
Q

Human to human involved transmitted by corneal and organ transplants

A

Liver and kidney

51
Q

Proved effective at controlling rabies in foxes in Europe

A

V-RG

52
Q

Synthesized by membrane- bound ribosome attach to host cell and internalized by Endocytosis. Generates neutralizing antibodies

A

G

53
Q

Major structure protein, protects the RNA from ribonuclease digestion

A

N

54
Q

Constitute the RNA dependent RNA pol which transcribe the viral genomic RNA

A

L and NS

55
Q

Matrix protein

Lies between envelope and nucleocapsid

A

M

56
Q

Primary test to determine the presence of rabies

A

FAT

57
Q

Highly sensitive test for rabies which takes 2-3 weeks to complete

A

Mouse inoculation test

58
Q

Used to confirm the diagnosis

A

Sellers stain

59
Q

Perfectly tolerated and safe but the cost is expensive
Must be infiltrated around the bite site
Immune

A

HRIG

60
Q

From horses so skin test is required

Effective and safe with an adverse reaction rate of

A

ERIG

61
Q

Ideal for human

A

Human diploid cell vaccine

62
Q

Cheaper

A

Purified Veronica Cell Rabies Vaccine

63
Q

Shaped

A

Rod or bullet shaped

Microbiology 2nd Sem Finals (2 decks)

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