AA @ precursors for NTs

Question 1

AA’s can synthesize 6 molecule classes

Answer 1

porphyrins
creatines
NT
Purines
Pyrimidines
Other N containing compounds

Question 2

Tyrosine Hydrolase

Answer 2

Tyr to Dopa

Needs tetrahydropterin and O2

Question 3

DOPA carboxylase

Answer 3

Dopa to dopamine

-loses carboxylase

Question 4

Dopamine B-hydroxylase

Answer 4

Dopamine to Norepi

• needs ascorbate
• adds OH

Question 5

Norepi to epi

Answer 5

phenylethanolamine N methyl transferase

• needs SAM, B12, and Folate
• adds methyl

Question 6

Catecholamine’s all have…

Answer 6

Two hydroxyls on phenyl ring

Question 7

Other AA’s making NT’s + pathway

Answer 7

Decarboxylation

GABA from glutamate
Histamine from histidine
Serotonin from tryptophan

Question 8

Creatine synthesis + high levels

Answer 8

From argnine and glycine

• uses SAM
• made in liver as storage for ATP

when muscle dies-creatine is dumped into circulation-MI

Question 9

Glutathione synthesis

Answer 9

Glutate, cystene and ATP
Glycine and ATP
GSH (glutathione) reversible with GSSG (gluthatione disulfide)

see if remember what this does from other NC

Question 10

Tetrahydrobioptern as a cofcator for what 3 pathways

Answer 10

Phenylalanine to Try

Try to DOPA

Trp to serotonin