Final Exam Review - Exam 4

Question 1

1. Which dosage form is anticipated to stay in the fed stomach for a longer period of
time?
A. Pellets
B. Liquids
C. Disintegrated tablets
D. Extended release dosage forms

Answer 1

D. Extended release dosage forms

Question 2

2. In order that the dosage form (drug) will reach the intestine rapidly, how should the drug be taken?
   A. With food
   B. With water

Answer 2

B. With water

Question 3

3. Passive diffusion is the preferred route of transport for relatively small___________
   A. Hydrophilic molecules
   B. Lipophilic molecules

Answer 3

B. Lipophilic molecules

Question 4

4. In active transport, the molecules move from regions of:
   A. Low concentration to those of high concentration
   B. High concentration to those of low concentration

Answer 4

A. Low concentration to those of high concentration

Question 5

5. Transporters for which of the following compounds would be the most relevant for the absorption of drugs?
A. Short peptides
B. Sugars
C. Electrolytes
D. Vitamins (B1, B2, B12)
E. Bile salts

Answer 5

A. Short peptides

Question 6

6. Which mechanism(s) require (s) a concentration gradient of the drug as its/their driving force?
   A. Passive Diffusion only
   B. Carrier-mediated transport: Active Transport
   C. Carrier-mediated transport: Facilitated Diffusion only
   D. A and B
   E. A and C

Answer 6

E. A and C

Question 7

7. The diffusion coefficient, D, of the drug in the GI fluids may be ____________ by the presence of food
   A. Increased
   B. Decreased

Answer 7

B. Decreased

Question 8

8. An increase in gastric and/or intestinal motility may __________ the dissolution rate of a sparingly soluble drug
   A. Increase
   B. Decrease

Answer 8

A. Increase

Question 9

9. Solubility of weak acids is:
   A. Higher in stomach than small intestine
   B. Higher in small intestine than stomach

Answer 9

B. Higher in small intestine than stomach

Question 10

10. Which drug is more appropriate to treat toothache?
    A. Naproxen
    B. Naproxen sodium
    C. Naproxen and naproxen sodium are equally appropriate

Answer 10

B. Naproxen sodium

Question 11

11. Cyclodextrin complexes are:
    A. Reversible
    B. Irreversible

Answer 11

A. Reversible

Question 12

12. When a drug is unstable in gastric fluid, to minimize its degradation in gastric fluid, should you increase/decrease its dissolution in gastric fluid?
    A. Increase
    B. Decrease

Answer 12

B. Decrease

Question 13

13. Choose the correct statement:
    A. Most drugs are weak electrolytes
    B. Most drugs are strong electrolytes
    C. The number of drugs that are weak electrolytes is approximately similar
    to the number of drugs that are strong electrolytes

Answer 13

A. Most drugs are weak electrolytes

Question 14

14. Which form of drugs that are weak acids or bases will better penetrate through the GI epithelium?
    A. Ionized
    B. Unionized
    C. Ionization does not affect penetration through GI epithelium

Answer 14

B. Unionized

Question 15

15. Drugs that are poorly lipid soluble (=polar) (log P

Answer 15

A. Paracellular pathway

Question 16

16. Which statement is true?
    A. Most drugs are more stable in liquid dosage forms
    B. Most drugs are more stable in solid dosage forms
    C. There is no connection between drug stability and dosage form

Answer 16

B. Most drugs are more stable in solid dosage forms

Question 17

17. One has two pieces: a longer body and a shorter cap; the other has only one piece; which is which?
    A. Hard=2 pieces; soft=1 piece
    B. Hard=1 piece; soft= 2 pieces

Answer 17

A. Hard=2 pieces; soft=1 piece