4C Apoptosis Flashcards
1
Q
Define apoptosis
A
Programmed cell death
2
Q
What are the two apoptosis pathways?
A
Death receptor (external) pathway and mitochondrial (internal) pathway
3
Q
Explain death receptor pathway
A
death signalling molecules detect external DNA damage and attach to death receptor on plasma membrane
4
Q
Explain mitochondrial pathway
A
mitochondria detects internal damage and releases cytochrome c.
5
Q
Stages of Apoptosis
A
- Signalling
- Caspases activated.
- Digestion of cell contents
- Cell shrinks.
- Membrane blebbing – apoptotic bodies form
- Phagocyte cleans everything up.
6
Q
Does apoptosis require ATP?
A
Yes
7
Q
Not enough apoptosis leads to…
A
formation of tumors that can be cancerous
8
Q
Too much apoptosis leads to…
A
Alzheimer’s
