4TH QUESTION GROUP Flashcards

(53 cards)

1
Q

intermediary metabolism

A

the reactions between the absorption of feedstuff and excretion of the end products (ATP and heat produced)

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2
Q

biological oxidation

A

oxidative processes in cells (mitochondria), carb, lipids + proteins will be degraded = ATP, heat, CO2 + H20 production

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3
Q

oxidative phosphorylation

A

production in ATP by a protive motive force in the respiratory chain

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4
Q

catabolism

A

degradative processes forming ATP

substrates (carbs, lipids, proteins) are degraded into common intermediates like acetyl CoA which end up in hte citric acid cycle and then the electron transport chain to undergo ox. phosphory.

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5
Q

anabolism

A

synthetic processes

net product is ATP

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6
Q

amphibolic reactions

A

involve annabolism + catabolism

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7
Q

three stages of energy extraction

A

formation of smaller molecules (protein to aa)

formation of simple units (bd of aa etc. into acetyl CoA)

citric acid cycle, respiratory chain + oxidative phosporylation
(further oxidation of acetyl-CoA to generate ATP)

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8
Q

2 methods of producing ATP from different substrates

A

oxidative phosphorylation

substrate-level phosphorylation

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9
Q

substrate level phosphorylation

A

direct phosphorylation of ADP from phosphorylated intermediates that will be seen during glycolysis + CAC

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10
Q

what type of bonds are phosphoanydride bonds?

A

high energy bonds

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11
Q

high energy bonds

A

phosphate group with a high free energy or hydrolysis

high group transfer potential

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12
Q

ATP function

A

energy source

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13
Q

AMP reaction

A

energy sensor + regulator of metabolism

AMP stimulates metabolic pathways that produce ATP

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14
Q

ATP structure

A

adenine
ribose
3 phosphates (phosphoanhydride linkages)

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15
Q

what phosphate linkage is used in nerve + muscle cells for storage of -P

A

phosphocreatine (creatine phosphate)

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16
Q

when is phosphocreatine produced

A

when ATP levels are high

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17
Q

during exercise, what happens to phosphocreatine

A

ATP depleted, phosphate transferred from phophocreatine to ADP to replenish ATP

phosphocreatine + ADP - ATP + creatine (reversible)

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18
Q

regulator of creatine synthesis

A

Arg-Gly transamidinase

Argine, Glycine +
Creatine -

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19
Q

where does the synthesis of creatine occur

A

1st reaction: kidney

2nd reaction: liver

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20
Q

thioester

A

high energy bond
forms between a carboxyl group of acetic or fatty acid + thiol (SH) group

(acetyl - CoA)

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21
Q

carbohydrate functions

A

stored as glycogen in animals

supply carbon for synthesis of other compounds

the simple sugars converted into starch, fats, enzymes, DNA/RNA + ATP

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22
Q

groups of carbohydrates

A

monosacharides
(glucose, fructose, ribose)

diasaccharides (sucrose, maltose, lactose)

oligosaccharides

polysaccharides
(starch, cellulose, glycogen)

23
Q

how are monosaccharides classified

A

based on the number of carbons

based on their functional group (aldoses + ketoses)

24
Q

aldoses

A

contain an aldehyde group (CHO)

25
ketoses
contain a ketone group (CO)
26
anomers
Anomers are cyclic monosaccharides or glycosides that are epimers, differing from each other in the configuration of C-1 if they are aldoses or in the configuration at C-2 if they are ketoses.
27
2 types of anomers
alpha -D-(+)-glucopyranose | beta -D-(+)-glucopyranose
28
what is the difference between alpha -D-(+)-glucopyranose | beta -D-(+)-glucopyranose
OH at C1 below the ring - ALPHA above the ring - BETA
29
monosaccharides derivates
``` Gluconic acid (sugar acid) Glucuronic acid (sugar acid) Glucosamine (amino sugar) Galactosamine (amino sugar) N-Acety-D-Glucosamine (acetylated amino sugar) N-Acety-D-Galactosamine (acetylated aminosugar) Ribitol, sorbitol (sugar alcohols) ```
30
gluconic acid - glucuronic acid
the aldehyde at C1 or the hydroxyl on the terminal carbon is oxidised to a caboxylic acid
31
Ribitol, sorbitol (sugar alcohols)
lack an aldehyde or ketone group, they are reduced to alcohols ribitol - reduced from ribose sorbitol - reduced from glucose
32
disaccharides
2 monosaccharides bound with glycosydic bond (glucose, galactose, fructose)
33
homopolysaccharides
are polysaccharides composed of a single type of sugar monomer starch + glycogen
34
what makes up starch
amylose (20%) (watersoluble, non-branching) amylopectin (80%) (not water soluble, branching)
35
branching point of starch
25th glucose monomer
36
starch is degraded by what
amylase
37
where does glycogen accumulate
animal storage product | liver + muscle
38
branching point of glycogen
8-10th glucose monomer
39
glycogen is degraded by what
amylase
40
hyaluronic acid
a glucosaminoglycan with a repeating disaccharide consisting of glucuronic acid and N-acetyl-D-glucosamine
41
where is hyaluronic acid found
vitreous humor of eye synovial fliud coat of ovum
42
how is hyaluronic acid degradaded
hyaluronidase
43
chondroitin sulphate
a glycosaminoglycan | vitamin A has a role in sulphate group binding
44
why is is chondroitin sulphate important
important structural component of cartilage bone formation
45
heparin
soluble glycosaminoglycan
46
where is heparin found
granules of mast cells in the liver and lung
47
what does heparin do in the blood
inhibits clot formation by interacting with the protein antithrombin
48
heteropolysaccharides
glycoproteins
49
glycoprotein vs glycosaminoglycan
the carbohydrate portion of glycoproteins is shorter and branched and contains manose, glucose, galactose + amino derivates
50
glycogenesis
glucose-6-phosphate to glycogen in the liver | addition of one glucose to glycogen
51
glycogenolysis
glucose-6-phosphate to glucose
52
glycolysis
during strenuous exercise, glycogen broken down to glucose-6-phosphate
53
gluconeogenesis
biosynthesis of glucose from a non carbohydrate sources