4th Year Dermatitis Flashcards
which skin layers does dermatitis affect?
epidermis and dermis
what is dermatitis
inflammatory condition with spongiosis, varying degrees of acanthosis and superficial infiltrate
what clinically correlates with spongiosis?
crusting
endogenous types of dermatitis
atopic seborrheic lichen simplex chronicus discoid nodular prurigo pomphylax
exogenous types of dermatitis
irritant
allergic
atopic eczema appearance in the young
early infancy on face and extensor surfaces before later developing into typical flexural pattern
criteria for atopic eczema diagnosis
itching plus 3 or more of:
- visible flexural rash
- history of flexural rash
- PH of atopy or first degree relative
- dry skin in past year
- onset before 2 years
where is the filaggrin protein present?
in keratohyalin granules in the granular layer
what does mutations to the filaggrin protein cause?
ichthyosis
predisposes to atopy
management of atopy
emollients topical steroids calcineurin inhibitors bandages/ wet wraps antihistamines phototherapy systemic agents
adverse of topical steroids
skin thinning increased infection telangiectasia acne systemic absorption poor growth/ Cushing's
levels of topical steroids
hydrocortisone
eumovate
betnovate
dermovate
examples of calcineurin inhibitors
tacrolismus
pimecrolimus
chemicals used in wet wraps/ bandages?
zinc oxide +/ - tar
ichthammol
zipzocs
bug in infected eczema
staph aureus usually
if HSV admission needed
