#5: Intro to Neuro Disorders Flashcards Preview

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Flashcards in #5: Intro to Neuro Disorders Deck (12)
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1
Q

Mc degenerative disorder of the motor neuron system

A

ALS

2
Q

Huntington’s chorea treatment:

A
  • purely SXS tx; dz progression cannot be halted
  • Haldol- behavior tx
  • Reserpine- dyskinesia tx
3
Q

This drug is proven to prolong tracheostomy free survival by 2-3 months w/ ALS?

A

Riluzole (Rilutek)

4
Q

2 drugs recommended for SXS tx w/ ALS?

A
  • Baclofen (Lioresal)

- Tizanidine (Zanaflex)

5
Q

Best predictor of prognosis for ALS:

A

rate of dz progression

6
Q

Median survival for ALS:

A

3 yrs from clinically apparent dz

– ALS is fatal

7
Q

Pharmological tx in CRPS and the drug SXS or targets: (4)

A

1- Prednisone: Q30-40 mg QD and tapered over 2-4 wks for mobility, pain and stiffness
2- IV Calcitonin for decreasing inflammation
3- NSAIDs for SXS relief
4- Sympathetic blockade: lidocaine or bupivicaine (+/- epinephrine): blocks the efferent SNS impulses from the affected limb; may cause I/L Horner’s syndrome

8
Q

Best prognosis w/ CRPS is when:

A
  • detected and appropriately cared for early in the dz course (MC w/ children)
9
Q

List the medications may cause peripheral neuropathy: (4 major groups)

A

CASP

  • MC* w/ Chemo drugs- vincristine, cisplatin, taxol
  • Abx- metronidazole, isoniazid, linezolid (>21 days), fluoroquinolone, nitrofurantoin
  • Statins
  • Phenytoin
10
Q

Initial study of choice w. peripheral neuropathy:

A

EMG/NCS

if + then rq bx and directed lab eval

11
Q

MC inherited neuro disorder causing neuropathy w/o any metabolic cause:

A

Charcot-Marie-Tooth Dz (CMT)

12
Q

CMT its typically present w/:

A

SXS begin in the first 20 years of life w/ tripping over feet, increased falls, and clumsiness