Eicasinoids

Question 1

Zafirlukast

Answer 1

Pharmacokinetics: oral administration and metabolized by CYP2c9
Mechanism: cysteine leukotrienes receptor antagonist
Adverse effects: minimal
Therapeutic: prophylaxis and chronic treatment of asthma

Question 2

Zileuton

Answer 2

Pharmacokinetics: oral preparation and metabolized by CYPs
Mechanism: inhibit 5-lipoxygenase and no production of any leukotrienes
Adverse effects: few and some increase in liver enzymes
Therapeutic use: prophylaxis and chronic treatment of asthma (not acute treatment)