Breast Pathology Flashcards

1
Q

What percentage of breast tumors occur in secreting cells (located over myoepithelium)?

A

99 percent

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2
Q

What are the three basic elements of the breast?

A

Skin/nipple, ducts/lobules, fibroadipose stroma

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3
Q

What is the young and old breast made up of primarily?

A

Young is largely fibrous stroma. Old is largely adipose stroma.

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4
Q

The closer pathology is to the nipple…

A

…the more likely to be benign.

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5
Q

Tumors that arise from the smaller apparatus of the duct system are…

A

…more likely to be malignant.

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6
Q

What three things make up the terminal duct lobular unit?

A

Ductules or acini, terminal duct, lobule

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7
Q

Where does Paget’s disease occur?

A

Nipple, lactiferous duct

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8
Q

Where does nipple adenoma occur?

A

Nipple

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9
Q

Where do papillomas occur in the breast?

A

lactiferous duct or segmental duct

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10
Q

Where does traumatic fat necrosis occur?

A

In the adipose tissue of the breast

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11
Q

Where does hyperplasia and most carcinoma occur?

A

Terminal duct (terminal duct lobule unit)

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12
Q

Where do fibroadenoma and cysts occur?

A

Lobule (of TDLU)

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13
Q

What population gets mastitis most often?

A

99 percent limited to women who are breastfeeding

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14
Q

What are minor considerations of female breast disease?

A

Non cystic, Nonproliferative diseases and Infrequent, miscellaneous disease

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15
Q

What are the non cystic, non proliferative diseases of the breast?

A

Mastitis, Fat necrosis (simulates Ca)

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16
Q

What are the infrequent, miscellaneous diseases of the breast?

A

Virginal hypertrophy, Hamartomas, Phylloides tumors, Rare tumors not unique to the breast

17
Q

What Ddx do you think of with an inflamed, red breast?

A

Acute Bacterial Mastitis (most common bacteria is Staph. aureus), Inflammatory breast cancer (bad stage! plugging lymphatics), Dermatitis (usually not unilateral).

18
Q

What are common breast disease considerations?

A

Benign tumors, Fibrocystic disease, Carcinoma

19
Q

The younger you get cancer…

A

…the more likely it is to be malignant, more likely to be a genetic cause.

20
Q

What percent of women n the US will have in-situ or invasive breast cancer?

A

12 percent

21
Q

What are Benign breast tumors?

A

Fibroadenoma, Lipoma

22
Q

What is fibrocystic breast disease?

A

Cystic change and epithelial hyperplasia

23
Q

What are the types of Carcinoma?

A

In-situ and Invasive

24
Q

What are fibroadenomas cousins to?

A

Phylloides tumor - low-grade (benign) and high-grade (malignant)