24 - Infections Flashcards

1
Q

astrocytes: what protein

A

glial fibrillary acidic protein GFAP

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2
Q

most abundant cell type in CNS?

A

astrocytes

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3
Q

types of astrocytes

A

Type I, Type II, fibrillary, protoplasmic, radial

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4
Q

astrocytes major functions (4)

A

biochemical support of endothelia cells that form BBB, provide nutrients to nervous tissue, maintain extracellular ion balance, role in repair/scarring process after injury

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5
Q

oligodendrocytes: what %? dervied from? what are they?

A

5 - 10 % of all CNS cells. neuroectoderm. myelin producing cells that provide structural support for axons satellite cells

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6
Q

major functions of astrocytes (2)

A

produce myelin = increase axonal transmission speed, reduce axonal capacitance during saltatory propagation

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7
Q

oligodendrocytes: prototype expressed proteins (3)

A

myelin basic protein MBP. proteolipid protein PLP. 2’3’ cyclic nucleotide 3’ phosphodiesterase CNPase

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8
Q

microglia: what %? derived from?

A

~10% of all CNS cells. from yolk sac, but also from infiltrating blood macrophages and monocytes.

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9
Q

major functions of microglia (2)

A

sentinel sensors of CNS, recognize + respond to potentially damaging stimuli (like injuries or infections)

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10
Q

what do microglia do (2)

A

phagocytose damaged cells, infectious agents, blood. produce inflammatory molecules.

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11
Q

3 prototype expressed proteins for microglia

A

MHC Class II, Iba-1, CD68

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12
Q

microglia: part of what immune system?

A

innate (first line non specific, rather than the adaptive)

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