Therapeutic Antibodies

Question 1

Targets VEGF; used to treat colorectal cancer and renal cell carcinoma

Answer 1

Bevacizumab

Question 2

Targets EGFR; used to treat stage IV colorectal cancer, as well as head and neck cancer

Answer 2

Cetuximab

Question 3

Targets CD20; used to treat B-cell non-Hodgkin lymphoma, CLL, RA, and ITP

Answer 3

Rituximab

Question 4

Targets HER2/neu; used to treat breast cancer

Answer 4

Trastuzumab

Question 5

Targets soluble TNF-alpha; used to treat IBD, RA, ankylosing spondylitis, and psoriasis

Answer 5

1. Adalimumab
2. Infliximab

Note: Etanercept is not listed here because it is a decoy TNF-alpha receptor and not a monoclonal antibody.

Question 6

Targets complement protein C5; used to treat paroxysmal nocturnal hemoglobinuria

Answer 6

Eculizumab

Question 7

Targets alpha4-integrin; used to treat multiple sclerosis and Crohn disease; risk of PML in pts with latent JC virus infection

Answer 7

Natalizumab

Question 8

Targets platelet glycoproteins IIb/IIIa; antiplatelet agent used to prevent ischemic complications in pts undergoing percutaneous coronary intervention

Answer 8

Abciximab

Question 9

Targets RANKL; used to treat osteoporosis; inhibits osteoclast maturation by mimicking osteoprotegerin

Answer 9

Denosumab

Question 10

Targets digoxin; antidote for digoxin toxicity

Answer 10

Digoxin immune Fab

Question 11

Targets IgE; used to treat allergic asthma; prevents IgE binding to Fc(epsilon)RI

Answer 11

Omalizumab

Question 12

Targets RSV F protein; used as RSV prophylaxis for high-risk infants

Answer 12

Palivizumab

Question 13

Targets VEGF; used to treat neovascular age-related macular degeneration

Answer 13

1. Ranibizumab

2. Bevacizumab

Question 14

Targets CD52; used to treat chronic lymphocytic leukemia (CLL)

Answer 14

Alemtuzumab