Vasculitides Flashcards
1
Q
Large vessel: takayasu’s arteritis
features/ key words (3)
A
- ‘pulseless’ disease
- japanese women
- vascu - absent pulses, bruit, claudication
2
Q
Large vessel: Temporal arteritis
Features (3)
Histo (2)
A
F
- elderyly; scalp tenderness, headache (temporal)
- jaw claudication, blurred vision
Raised ESR
Histo
- granulomatous transmural inflammation + giant cells + skip lesions
3
Q
Medium vessel: Polyarteritis Nodosa (PAN)
Main organ invovlement? infection assc? appearance on angiography?
A
- renal involvment is main feature
- can involve other organs but spares lungs
- assc with hep B infection
- nodular appearance on angiography - due to microaneurysms
4
Q
Medium vessel: Kawasaki disease
- age group
- features (4)
A
- Children
- fever > 5 days
- rash - red alms & soles with later desquamation
- inflammation of lips, mouth, tongue - strawberry tongue
- Cervical LNpathy
- coronary arteries may be affected (MI/ aneurysm)
- other wise self limiting
5
Q
Medium vessel: Buerger’s disease
A
heavy smokers
- inflammation of artereies of extremities, pain & ulceration
- angiogram - corckscrew appearance
6
Q
Small vessel: granulomatosis with polyangitis (aka Wegner)
- hallmark triad
- ab & ag it is directed against
A
Hallmark traid
- ENT - sinusitis, nose bleed, saddle nose
- lung - pulmonary haemorrhage
- kidney - cresenteric GN
ab
- c-ANCA - abs bind to cytoplasm antigens in neutrophils – proteinase 3
7
Q
Small vessel: Churg strauss (eosinophillic granulomatosis with polyangitis)
triad
ab & ag
A
Triad
- asthma
- eosinophilia
- vasculitis
ab - pANCA against myeloperoxidase
8
Q
Small vessel: Microscopic polyangitis
2 features
A
pulmonary renal syndrome:
- Pulm haemorrhage
- GN
also pANCA anti-MPO
9
Q
Small vessel: HSP
- which class of ab responsible?
- features (3)
A
- IgA mediated vasculitis
- children < 10
- preceding URTI
- palpable, purpuric rash (lowerlimbs, buttocks)
- GN, colicky abdopain
